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Development of a core outcome set for trials investigating the long-term management of bronchiectasis

Heterogeneity in outcomes measured in trials limits accurate comparison of bronchiectasis studies. A core outcome set (COS) is an agreed, standardized set of outcomes that should be measured in trials for specific clinical areas. A COS for bronchiectasis could encourage consistency in future studies...

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Detalles Bibliográficos
Autores principales: Spargo, Maureen, Ryan, Cristín, Downey, Damian, Hughes, Carmel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301837/
https://www.ncbi.nlm.nih.gov/pubmed/30278785
http://dx.doi.org/10.1177/1479972318804167
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author Spargo, Maureen
Ryan, Cristín
Downey, Damian
Hughes, Carmel
author_facet Spargo, Maureen
Ryan, Cristín
Downey, Damian
Hughes, Carmel
author_sort Spargo, Maureen
collection PubMed
description Heterogeneity in outcomes measured in trials limits accurate comparison of bronchiectasis studies. A core outcome set (COS) is an agreed, standardized set of outcomes that should be measured in trials for specific clinical areas. A COS for bronchiectasis could encourage consistency in future studies. An overview of systematic reviews and qualitative study on outcome selection in bronchiectasis informed an initial list of outcomes. A Delphi panel (n = 86) rated the importance of each outcome from 1 to 9 in 3 sequential questionnaires, as a means to achieve consensus: 1–3 = ‘of limited importance’; 4–6 = ‘important, but not critical’; and 7–9 = ‘critical’. Outcomes rated ‘critical’ by ≥70% of the panel were added to the COS. Eighty-two participants responded to the first questionnaire. Attrition between each questionnaire was 5%. After 3 rounds of questioning, 18 outcomes exceeded the threshold for consensus and were included in the COS. This study has achieved consensus on 18 outcomes that should be measured in trials of interventions for bronchiectasis. Selection of the highest ranked outcomes may represent a pragmatic means for comparison. Further research is required to condense the number of outcomes selected and to determine its relevance to interventions.
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spelling pubmed-63018372019-01-24 Development of a core outcome set for trials investigating the long-term management of bronchiectasis Spargo, Maureen Ryan, Cristín Downey, Damian Hughes, Carmel Chron Respir Dis Article Heterogeneity in outcomes measured in trials limits accurate comparison of bronchiectasis studies. A core outcome set (COS) is an agreed, standardized set of outcomes that should be measured in trials for specific clinical areas. A COS for bronchiectasis could encourage consistency in future studies. An overview of systematic reviews and qualitative study on outcome selection in bronchiectasis informed an initial list of outcomes. A Delphi panel (n = 86) rated the importance of each outcome from 1 to 9 in 3 sequential questionnaires, as a means to achieve consensus: 1–3 = ‘of limited importance’; 4–6 = ‘important, but not critical’; and 7–9 = ‘critical’. Outcomes rated ‘critical’ by ≥70% of the panel were added to the COS. Eighty-two participants responded to the first questionnaire. Attrition between each questionnaire was 5%. After 3 rounds of questioning, 18 outcomes exceeded the threshold for consensus and were included in the COS. This study has achieved consensus on 18 outcomes that should be measured in trials of interventions for bronchiectasis. Selection of the highest ranked outcomes may represent a pragmatic means for comparison. Further research is required to condense the number of outcomes selected and to determine its relevance to interventions. SAGE Publications 2018-10-03 /pmc/articles/PMC6301837/ /pubmed/30278785 http://dx.doi.org/10.1177/1479972318804167 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Spargo, Maureen
Ryan, Cristín
Downey, Damian
Hughes, Carmel
Development of a core outcome set for trials investigating the long-term management of bronchiectasis
title Development of a core outcome set for trials investigating the long-term management of bronchiectasis
title_full Development of a core outcome set for trials investigating the long-term management of bronchiectasis
title_fullStr Development of a core outcome set for trials investigating the long-term management of bronchiectasis
title_full_unstemmed Development of a core outcome set for trials investigating the long-term management of bronchiectasis
title_short Development of a core outcome set for trials investigating the long-term management of bronchiectasis
title_sort development of a core outcome set for trials investigating the long-term management of bronchiectasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301837/
https://www.ncbi.nlm.nih.gov/pubmed/30278785
http://dx.doi.org/10.1177/1479972318804167
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