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Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Inducible nitric oxide synthase (iNOS) plays a crucial role in controlling growth of Mycobacterium tuberculosis (M.tb), presumably via nitric oxide (NO) mediated killing. Here we show that leukocyte-specific deficiency of NO production, through targeted loss of the iNOS cofactor tetrahydrobiopterin...

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Detalles Bibliográficos
Autores principales:	McNeill, Eileen, Stylianou, Elena, Crabtree, Mark J., Harrington-Kandt, Rachel, Kolb, Anna-Lena, Diotallevi, Marina, Hale, Ashley B., Bettencourt, Paulo, Tanner, Rachel, O’Shea, Matthew K., Matsumiya, Magali, Lockstone, Helen, Müller, Julius, Fletcher, Helen A., Greaves, David R., McShane, Helen, Channon, Keith M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302098/ https://www.ncbi.nlm.nih.gov/pubmed/30573728 http://dx.doi.org/10.1038/s41467-018-07714-9

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