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Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses

Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. Herein, promoter methylation status of genes implicated in disease progression (CDKN2A and S...

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Detalles Bibliográficos
Autores principales:	Yao, Qiumei, Morgan, Gareth J., Chim, Chor Sang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302381/ https://www.ncbi.nlm.nih.gov/pubmed/30572945 http://dx.doi.org/10.1186/s13148-018-0597-6

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