Cargando…

New insights into the role of TREM2 in Alzheimer’s disease

Alzheimer’s disease (AD) is the leading cause of dementia. The two histopathological markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and neurofibrillary tangles of aggregated, abnormally hyperphosphorylated tau protein. The majority of AD cases are late-onset, after the age...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gratuze, Maud, Leyns, Cheryl E. G., Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302500/ https://www.ncbi.nlm.nih.gov/pubmed/30572908 http://dx.doi.org/10.1186/s13024-018-0298-9

Ejemplares similares

TREM2 function impedes tau seeding in neuritic plaques
por: Leyns, Cheryl E.G., et al.
Publicado: (2019)

Insights from new in vivo models of TREM2 variants
por: Jain, Nimansha, et al.
Publicado: (2023)

Glial contributions to neurodegeneration in tauopathies
por: Leyns, Cheryl E. G., et al.
Publicado: (2017)

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
por: Leyns, Cheryl E. G., et al.
Publicado: (2017)

The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives
por: Wolfe, Cody M., et al.
Publicado: (2018)

TREM2 regulates innate immunity in Alzheimer’s disease
por: Li, Jiang-Tao, et al.
Publicado: (2018)

TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model
por: Wang, Yaming, et al.
Publicado: (2015)

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease
por: Golde, Todd E, et al.
Publicado: (2013)

The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders
por: Yaghmoor, Faris, et al.
Publicado: (2014)

The role of TREM2 in Alzheimer’s disease: from the perspective of Tau
por: Huang, Wendi, et al.
Publicado: (2023)

TREM2 ectodomain and its soluble form in Alzheimer’s disease
por: Yang, Jiaolong, et al.
Publicado: (2020)

TREM2 dependent and independent functions of microglia in Alzheimer’s disease
por: Hou, Jinchao, et al.
Publicado: (2022)

Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease
por: Jefferies, Wilfred A, et al.
Publicado: (2013)

The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer’s Disease
por: Zhong, Li, et al.
Publicado: (2019)

Function of TREM1 and TREM2 in Liver-Related Diseases
por: Sun, Huifang, et al.
Publicado: (2020)

TREM2 in Neurodegenerative Diseases
por: Jay, Taylor R., et al.
Publicado: (2017)

TREM2 deficiency eliminates TREM2(+) inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
por: Jay, Taylor R., et al.
Publicado: (2015)

CSF sTREM2: marking the tipping point between preclinical AD and dementia?
por: Schindler, Suzanne E, et al.
Publicado: (2016)

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease
por: Zhou, Yingyue, et al.
Publicado: (2018)

Plasmonic Interferometers as TREM2 Sensors for Alzheimer’s Disease
por: Li, Dingdong, et al.
Publicado: (2021)

TREM2 as an evolving therapeutic target in Alzheimer’s disease
por: George, Jacob
Publicado: (2023)

Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid‐soluble TREM2
por: Wang, Zuo‐Teng, et al.
Publicado: (2023)

Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease
por: Henjum, Kristi, et al.
Publicado: (2016)

Insights into Macrophage/Monocyte-Endothelial Cell Crosstalk in the Liver: A Role for Trem-2
por: Coelho, Inês, et al.
Publicado: (2021)

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism
por: Zheng, Honghua, et al.
Publicado: (2018)

Reduced TREM2 activation in microglia of patients with Alzheimer's disease
por: Okuzono, Yuumi, et al.
Publicado: (2021)

Does Soluble TREM2 Protect Against Alzheimer's Disease?
por: Brown, Guy C., et al.
Publicado: (2022)

TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer’s Disease
por: La Rosa, Francesca, et al.
Publicado: (2023)

APOE and TREM2 regulate amyloid responsive microglia in Alzheimer’s disease
por: Nguyen, Aivi T., et al.
Publicado: (2020)

TREM2 is associated with increased risk for Alzheimer’s disease in African Americans
por: Jin, Sheng Chih, et al.
Publicado: (2015)

Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease
por: Hok-A-Hin, Yanaika S., et al.
Publicado: (2023)

Regulation of brain insulin signaling: A new function for tau
por: Gratuze, Maud, et al.
Publicado: (2017)

Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2
por: Haure-Mirande, Jean-Vianney, et al.
Publicado: (2022)

Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease
por: Abduljaleel, Zainularifeen, et al.
Publicado: (2014)

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and - independent cellular responses in Alzheimer’s disease
por: Zhou, Yingyue, et al.
Publicado: (2020)

Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants
por: Dash, Raju, et al.
Publicado: (2020)

Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease
por: Basha, SK Chand, et al.
Publicado: (2023)

TREM2 in CNS homeostasis and neurodegenerative disease
por: Painter, Meghan M., et al.
Publicado: (2015)

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology
por: Gratuze, Maud, et al.
Publicado: (2017)

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
por: Heslegrave, Amanda, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5elgcmrdca0firaqm3gs39rpuc