Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART

A 27-year-old male with HIV-associated naïve and high-risk Burkitt’s lymphoma sequentially received short-term, high-dose non-myeloablative chemotherapy and autologous CD34-positive stem cell transfusion in the setting of combined antiretroviral therapy (cART). Prompt hematopoietic recovery was obse...

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Autores principales: Min, Haiyan, Yang, Jianwei, Wang, Sanbin, Tao, Pengfei, Song, Yuqin, Wang, Xiaopei, Li, Huiqin, Yang, Xinping, Dong, Xingqi, Wang, Fu-Sheng, Shi, Ming, Wang, Xicheng, Xu, Ruonan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302511/
https://www.ncbi.nlm.nih.gov/pubmed/30572947
http://dx.doi.org/10.1186/s13287-018-1089-5
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author Min, Haiyan
Yang, Jianwei
Wang, Sanbin
Tao, Pengfei
Song, Yuqin
Wang, Xiaopei
Li, Huiqin
Yang, Xinping
Dong, Xingqi
Wang, Fu-Sheng
Shi, Ming
Wang, Xicheng
Xu, Ruonan
author_facet Min, Haiyan
Yang, Jianwei
Wang, Sanbin
Tao, Pengfei
Song, Yuqin
Wang, Xiaopei
Li, Huiqin
Yang, Xinping
Dong, Xingqi
Wang, Fu-Sheng
Shi, Ming
Wang, Xicheng
Xu, Ruonan
author_sort Min, Haiyan
collection PubMed
description A 27-year-old male with HIV-associated naïve and high-risk Burkitt’s lymphoma sequentially received short-term, high-dose non-myeloablative chemotherapy and autologous CD34-positive stem cell transfusion in the setting of combined antiretroviral therapy (cART). Prompt hematopoietic recovery was observed after 2 weeks and clinical remission from Burkitt’s lymphoma within approximately 30 months after transplantation. The HIV RNA load was inhibited persistently, and drug resistance was not observed. The CD4+ T cell count approached 323 cells/μL in a recent follow-up study. This case suggests that the use of intensive non-myeloablative chemotherapy with transplantation, combined with antiretroviral therapy, in HIV-related naive and high-risk Burkitt’s lymphoma was tolerated and safe.
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spelling pubmed-63025112018-12-31 Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART Min, Haiyan Yang, Jianwei Wang, Sanbin Tao, Pengfei Song, Yuqin Wang, Xiaopei Li, Huiqin Yang, Xinping Dong, Xingqi Wang, Fu-Sheng Shi, Ming Wang, Xicheng Xu, Ruonan Stem Cell Res Ther Short Report A 27-year-old male with HIV-associated naïve and high-risk Burkitt’s lymphoma sequentially received short-term, high-dose non-myeloablative chemotherapy and autologous CD34-positive stem cell transfusion in the setting of combined antiretroviral therapy (cART). Prompt hematopoietic recovery was observed after 2 weeks and clinical remission from Burkitt’s lymphoma within approximately 30 months after transplantation. The HIV RNA load was inhibited persistently, and drug resistance was not observed. The CD4+ T cell count approached 323 cells/μL in a recent follow-up study. This case suggests that the use of intensive non-myeloablative chemotherapy with transplantation, combined with antiretroviral therapy, in HIV-related naive and high-risk Burkitt’s lymphoma was tolerated and safe. BioMed Central 2018-12-20 /pmc/articles/PMC6302511/ /pubmed/30572947 http://dx.doi.org/10.1186/s13287-018-1089-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Min, Haiyan
Yang, Jianwei
Wang, Sanbin
Tao, Pengfei
Song, Yuqin
Wang, Xiaopei
Li, Huiqin
Yang, Xinping
Dong, Xingqi
Wang, Fu-Sheng
Shi, Ming
Wang, Xicheng
Xu, Ruonan
Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART
title Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART
title_full Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART
title_fullStr Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART
title_full_unstemmed Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART
title_short Remission of HIV-related naïve and high-risk Burkitt’s lymphoma treated by autologous stem cell transplantation plus cART
title_sort remission of hiv-related naïve and high-risk burkitt’s lymphoma treated by autologous stem cell transplantation plus cart
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302511/
https://www.ncbi.nlm.nih.gov/pubmed/30572947
http://dx.doi.org/10.1186/s13287-018-1089-5
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