Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H(+) via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). We report that syrosingopine, an anti-hypertensive drug, is a dual MCT1 and MCT4 inhibitor (with 60-fold higher pot...

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Detalles Bibliográficos
Autores principales: Benjamin, Don, Robay, Dimitri, Hindupur, Sravanth K., Pohlmann, Jens, Colombi, Marco, El-Shemerly, Mahmoud Y., Maira, Sauveur-Michel, Moroni, Christoph, Lane, Heidi A., Hall, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302548/
https://www.ncbi.nlm.nih.gov/pubmed/30540938
http://dx.doi.org/10.1016/j.celrep.2018.11.043

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