Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis

The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to de...

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Autores principales: Kessler, Haeja, Jiang, Kaiyu, Jarvis, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302745/
https://www.ncbi.nlm.nih.gov/pubmed/30619322
http://dx.doi.org/10.3389/fimmu.2018.02964
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author Kessler, Haeja
Jiang, Kaiyu
Jarvis, James N.
author_facet Kessler, Haeja
Jiang, Kaiyu
Jarvis, James N.
author_sort Kessler, Haeja
collection PubMed
description The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns.
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spelling pubmed-63027452019-01-07 Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis Kessler, Haeja Jiang, Kaiyu Jarvis, James N. Front Immunol Immunology The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns. Frontiers Media S.A. 2018-12-14 /pmc/articles/PMC6302745/ /pubmed/30619322 http://dx.doi.org/10.3389/fimmu.2018.02964 Text en Copyright © 2018 Kessler, Jiang and Jarvis. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kessler, Haeja
Jiang, Kaiyu
Jarvis, James N.
Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_full Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_fullStr Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_full_unstemmed Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_short Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_sort using chromatin architecture to understand the genetics and transcriptomics of juvenile idiopathic arthritis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302745/
https://www.ncbi.nlm.nih.gov/pubmed/30619322
http://dx.doi.org/10.3389/fimmu.2018.02964
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