Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities

Designed nanobody‐linked synthetic consortia for microbiota dysbiosis therapies. A. Nanobodies (Nb) are selected for specific antigens on target bacteria destined for a synthetic therapy consortium that may consist of two (B) or multiple (C) members. For the treatment of dysbiosis co‐morbidities req...

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Detalles Bibliográficos
Autores principales: Timmis, Kenneth, Timmis, James Kenneth, Brüssow, Harald, Fernández, Luis Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Crystal Ball
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302794/
https://www.ncbi.nlm.nih.gov/pubmed/30575298
http://dx.doi.org/10.1111/1751-7915.13355
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author Timmis, Kenneth
Timmis, James Kenneth
Brüssow, Harald
Fernández, Luis Ángel
author_facet Timmis, Kenneth
Timmis, James Kenneth
Brüssow, Harald
Fernández, Luis Ángel
author_sort Timmis, Kenneth
collection PubMed
description Designed nanobody‐linked synthetic consortia for microbiota dysbiosis therapies. A. Nanobodies (Nb) are selected for specific antigens on target bacteria destined for a synthetic therapy consortium that may consist of two (B) or multiple (C) members. For the treatment of dysbiosis co‐morbidities requiring two functionally distinct consortia, these may be linked through a common member to generate a single bi‐functional microbiota therapy (D). [Image: see text]
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spelling pubmed-63027942018-12-31 Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities Timmis, Kenneth Timmis, James Kenneth Brüssow, Harald Fernández, Luis Ángel Microb Biotechnol Crystal Ball Designed nanobody‐linked synthetic consortia for microbiota dysbiosis therapies. A. Nanobodies (Nb) are selected for specific antigens on target bacteria destined for a synthetic therapy consortium that may consist of two (B) or multiple (C) members. For the treatment of dysbiosis co‐morbidities requiring two functionally distinct consortia, these may be linked through a common member to generate a single bi‐functional microbiota therapy (D). [Image: see text] John Wiley and Sons Inc. 2018-12-21 /pmc/articles/PMC6302794/ /pubmed/30575298 http://dx.doi.org/10.1111/1751-7915.13355 Text en © 2018 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Crystal Ball
Timmis, Kenneth
Timmis, James Kenneth
Brüssow, Harald
Fernández, Luis Ángel
Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities
title Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities
title_full Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities
title_fullStr Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities
title_full_unstemmed Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities
title_short Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities
title_sort synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities
topic Crystal Ball
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302794/
https://www.ncbi.nlm.nih.gov/pubmed/30575298
http://dx.doi.org/10.1111/1751-7915.13355
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