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Measurement of liver iron by magnetic resonance imaging in the UK Biobank population
The burden of liver disease continues to increase in the UK, with liver cirrhosis reported to be the third most common cause of premature death. Iron overload, a condition that impacts liver health, was traditionally associated with genetic disorders such as hereditary haemochromatosis, however, it...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303057/ https://www.ncbi.nlm.nih.gov/pubmed/30576354 http://dx.doi.org/10.1371/journal.pone.0209340 |
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author | McKay, Andy Wilman, Henry R. Dennis, Andrea Kelly, Matt Gyngell, Michael L. Neubauer, Stefan Bell, Jimmy D. Banerjee, Rajarshi Thomas, E. Louise |
author_facet | McKay, Andy Wilman, Henry R. Dennis, Andrea Kelly, Matt Gyngell, Michael L. Neubauer, Stefan Bell, Jimmy D. Banerjee, Rajarshi Thomas, E. Louise |
author_sort | McKay, Andy |
collection | PubMed |
description | The burden of liver disease continues to increase in the UK, with liver cirrhosis reported to be the third most common cause of premature death. Iron overload, a condition that impacts liver health, was traditionally associated with genetic disorders such as hereditary haemochromatosis, however, it is now increasingly associated with obesity, type-2 diabetes and non-alcoholic fatty liver disease. The aim of this study was to assess the prevalence of elevated levels of liver iron within the UK Biobank imaging study in a cohort of 9108 individuals. Magnetic resonance imaging (MRI) was undertaken at the UK Biobank imaging centre, acquiring a multi-echo spoiled gradient-echo single-breath-hold MRI sequence from the liver. All images were analysed for liver iron and fat (expressed as proton density fat fraction or PDFF) content using LiverMultiScan. Liver iron was measured in 97.3% of the cohort. The mean liver iron content was 1.32 ± 0.32 mg/g while the median was 1.25 mg/g (min: 0.85 max: 6.44 mg/g). Overall 4.82% of the population were defined as having elevated liver iron, above commonly accepted 1.8 mg/g threshold based on biochemical iron measurements in liver specimens obtained by biopsy. Further analysis using univariate models showed elevated liver iron to be related to male sex (p<10(−16), r(2) = 0.008), increasing age (p<10(−16), r(2) = 0.013), and red meat intake (p<10(−16), r(2) = 0.008). Elevated liver fat (>5.6% PDFF) was associated with a slight increase in prevalence of elevated liver iron (4.4% vs 6.3%, p = 0.0007). This study shows that population studies including measurement of liver iron concentration are feasible, which may in future be used to better inform patient stratification and treatment. |
format | Online Article Text |
id | pubmed-6303057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63030572019-01-08 Measurement of liver iron by magnetic resonance imaging in the UK Biobank population McKay, Andy Wilman, Henry R. Dennis, Andrea Kelly, Matt Gyngell, Michael L. Neubauer, Stefan Bell, Jimmy D. Banerjee, Rajarshi Thomas, E. Louise PLoS One Research Article The burden of liver disease continues to increase in the UK, with liver cirrhosis reported to be the third most common cause of premature death. Iron overload, a condition that impacts liver health, was traditionally associated with genetic disorders such as hereditary haemochromatosis, however, it is now increasingly associated with obesity, type-2 diabetes and non-alcoholic fatty liver disease. The aim of this study was to assess the prevalence of elevated levels of liver iron within the UK Biobank imaging study in a cohort of 9108 individuals. Magnetic resonance imaging (MRI) was undertaken at the UK Biobank imaging centre, acquiring a multi-echo spoiled gradient-echo single-breath-hold MRI sequence from the liver. All images were analysed for liver iron and fat (expressed as proton density fat fraction or PDFF) content using LiverMultiScan. Liver iron was measured in 97.3% of the cohort. The mean liver iron content was 1.32 ± 0.32 mg/g while the median was 1.25 mg/g (min: 0.85 max: 6.44 mg/g). Overall 4.82% of the population were defined as having elevated liver iron, above commonly accepted 1.8 mg/g threshold based on biochemical iron measurements in liver specimens obtained by biopsy. Further analysis using univariate models showed elevated liver iron to be related to male sex (p<10(−16), r(2) = 0.008), increasing age (p<10(−16), r(2) = 0.013), and red meat intake (p<10(−16), r(2) = 0.008). Elevated liver fat (>5.6% PDFF) was associated with a slight increase in prevalence of elevated liver iron (4.4% vs 6.3%, p = 0.0007). This study shows that population studies including measurement of liver iron concentration are feasible, which may in future be used to better inform patient stratification and treatment. Public Library of Science 2018-12-21 /pmc/articles/PMC6303057/ /pubmed/30576354 http://dx.doi.org/10.1371/journal.pone.0209340 Text en © 2018 McKay et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article McKay, Andy Wilman, Henry R. Dennis, Andrea Kelly, Matt Gyngell, Michael L. Neubauer, Stefan Bell, Jimmy D. Banerjee, Rajarshi Thomas, E. Louise Measurement of liver iron by magnetic resonance imaging in the UK Biobank population |
title | Measurement of liver iron by magnetic resonance imaging in the UK Biobank population |
title_full | Measurement of liver iron by magnetic resonance imaging in the UK Biobank population |
title_fullStr | Measurement of liver iron by magnetic resonance imaging in the UK Biobank population |
title_full_unstemmed | Measurement of liver iron by magnetic resonance imaging in the UK Biobank population |
title_short | Measurement of liver iron by magnetic resonance imaging in the UK Biobank population |
title_sort | measurement of liver iron by magnetic resonance imaging in the uk biobank population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303057/ https://www.ncbi.nlm.nih.gov/pubmed/30576354 http://dx.doi.org/10.1371/journal.pone.0209340 |
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