Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is p...

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Detalles Bibliográficos
Autores principales: Pettinati, Ilaria, Grzechnik, Pawel, Ribeiro de Almeida, Claudia, Brem, Jurgen, McDonough, Michael A, Dhir, Somdutta, Proudfoot, Nick J, Schofield, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303110/
https://www.ncbi.nlm.nih.gov/pubmed/30507380
http://dx.doi.org/10.7554/eLife.39865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303110/
https://www.ncbi.nlm.nih.gov/pubmed/30507380
http://dx.doi.org/10.7554/eLife.39865

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