Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

Elicitation of VRC01-class broadly neutralizing antibodies (bnAbs) is an appealing approach for a preventative HIV-1 vaccine. Despite extensive investigations, strategies to induce VRC01-class bnAbs and overcome the barrier posed by the envelope N276 glycan have not been successful. Here, we inferre...

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Detalles Bibliográficos
Autores principales: Bonsignori, Mattia, Scott, Eric, Wiehe, Kevin, Easterhoff, David, Alam, S. Munir, Hwang, Kwan-Ki, Cooper, Melissa, Xia, Shi-Mao, Zhang, Ruijun, Montefiori, David C., Henderson, Rory, Nie, Xiaoyan, Kelsoe, Garnett, Moody, M. Anthony, Chen, Xuejun, Joyce, M. Gordon, Kwong, Peter D., Connors, Mark, Mascola, John R., McGuire, Andrew T., Stamatatos, Leonidas, Medina-Ramírez, Max, Sanders, Rogier W., Saunders, Kevin O., Kepler, Thomas B., Haynes, Barton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303191/
https://www.ncbi.nlm.nih.gov/pubmed/30552024
http://dx.doi.org/10.1016/j.immuni.2018.10.015

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