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Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
Recent case reports describe an association between maternal paracetamol intake and fetal ductus arteriosus constriction or closure. To put these cases into perspective and explore causality, a structured literature search was conducted. The World Health Organization Uppsala Monitoring Centre (WHO–U...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303200/ https://www.ncbi.nlm.nih.gov/pubmed/30300944 http://dx.doi.org/10.1111/bcp.13778 |
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author | Allegaert, Karel Mian, Paola Lapillonne, Alexandre van den Anker, John N. |
author_facet | Allegaert, Karel Mian, Paola Lapillonne, Alexandre van den Anker, John N. |
author_sort | Allegaert, Karel |
collection | PubMed |
description | Recent case reports describe an association between maternal paracetamol intake and fetal ductus arteriosus constriction or closure. To put these cases into perspective and explore causality, a structured literature search was conducted. The World Health Organization Uppsala Monitoring Centre (WHO–UMC) causality tool was applied to the cases retrieved. The search resulted in 12 papers with 25 case descriptions, of which one case was classified as unlikely, nine as possible, 11 as probable and four as certain. Consequently, we concluded that a causal relationship between maternal paracetamol intake and fetal ductus arteriosus constriction or closure is likely. These findings suggest that pharmacovigilance studies on paracetamol safety during pregnancy are warranted to quantify the event and put the current findings into clinical perspective. Although analgesia during pregnancy and during the peripartum period is of obvious relevance, alternative analgesics such as opioids or other nonsteroidal anti‐inflammatory drugs also have side effects. |
format | Online Article Text |
id | pubmed-6303200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63032002018-12-31 Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis Allegaert, Karel Mian, Paola Lapillonne, Alexandre van den Anker, John N. Br J Clin Pharmacol Short Reports Recent case reports describe an association between maternal paracetamol intake and fetal ductus arteriosus constriction or closure. To put these cases into perspective and explore causality, a structured literature search was conducted. The World Health Organization Uppsala Monitoring Centre (WHO–UMC) causality tool was applied to the cases retrieved. The search resulted in 12 papers with 25 case descriptions, of which one case was classified as unlikely, nine as possible, 11 as probable and four as certain. Consequently, we concluded that a causal relationship between maternal paracetamol intake and fetal ductus arteriosus constriction or closure is likely. These findings suggest that pharmacovigilance studies on paracetamol safety during pregnancy are warranted to quantify the event and put the current findings into clinical perspective. Although analgesia during pregnancy and during the peripartum period is of obvious relevance, alternative analgesics such as opioids or other nonsteroidal anti‐inflammatory drugs also have side effects. John Wiley and Sons Inc. 2018-10-25 2019-01 /pmc/articles/PMC6303200/ /pubmed/30300944 http://dx.doi.org/10.1111/bcp.13778 Text en © 2018 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Short Reports Allegaert, Karel Mian, Paola Lapillonne, Alexandre van den Anker, John N. Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis |
title | Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis |
title_full | Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis |
title_fullStr | Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis |
title_full_unstemmed | Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis |
title_short | Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis |
title_sort | maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis |
topic | Short Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303200/ https://www.ncbi.nlm.nih.gov/pubmed/30300944 http://dx.doi.org/10.1111/bcp.13778 |
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