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Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis

Recent case reports describe an association between maternal paracetamol intake and fetal ductus arteriosus constriction or closure. To put these cases into perspective and explore causality, a structured literature search was conducted. The World Health Organization Uppsala Monitoring Centre (WHO–U...

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Autores principales: Allegaert, Karel, Mian, Paola, Lapillonne, Alexandre, van den Anker, John N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303200/
https://www.ncbi.nlm.nih.gov/pubmed/30300944
http://dx.doi.org/10.1111/bcp.13778
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author Allegaert, Karel
Mian, Paola
Lapillonne, Alexandre
van den Anker, John N.
author_facet Allegaert, Karel
Mian, Paola
Lapillonne, Alexandre
van den Anker, John N.
author_sort Allegaert, Karel
collection PubMed
description Recent case reports describe an association between maternal paracetamol intake and fetal ductus arteriosus constriction or closure. To put these cases into perspective and explore causality, a structured literature search was conducted. The World Health Organization Uppsala Monitoring Centre (WHO–UMC) causality tool was applied to the cases retrieved. The search resulted in 12 papers with 25 case descriptions, of which one case was classified as unlikely, nine as possible, 11 as probable and four as certain. Consequently, we concluded that a causal relationship between maternal paracetamol intake and fetal ductus arteriosus constriction or closure is likely. These findings suggest that pharmacovigilance studies on paracetamol safety during pregnancy are warranted to quantify the event and put the current findings into clinical perspective. Although analgesia during pregnancy and during the peripartum period is of obvious relevance, alternative analgesics such as opioids or other nonsteroidal anti‐inflammatory drugs also have side effects.
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spelling pubmed-63032002018-12-31 Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis Allegaert, Karel Mian, Paola Lapillonne, Alexandre van den Anker, John N. Br J Clin Pharmacol Short Reports Recent case reports describe an association between maternal paracetamol intake and fetal ductus arteriosus constriction or closure. To put these cases into perspective and explore causality, a structured literature search was conducted. The World Health Organization Uppsala Monitoring Centre (WHO–UMC) causality tool was applied to the cases retrieved. The search resulted in 12 papers with 25 case descriptions, of which one case was classified as unlikely, nine as possible, 11 as probable and four as certain. Consequently, we concluded that a causal relationship between maternal paracetamol intake and fetal ductus arteriosus constriction or closure is likely. These findings suggest that pharmacovigilance studies on paracetamol safety during pregnancy are warranted to quantify the event and put the current findings into clinical perspective. Although analgesia during pregnancy and during the peripartum period is of obvious relevance, alternative analgesics such as opioids or other nonsteroidal anti‐inflammatory drugs also have side effects. John Wiley and Sons Inc. 2018-10-25 2019-01 /pmc/articles/PMC6303200/ /pubmed/30300944 http://dx.doi.org/10.1111/bcp.13778 Text en © 2018 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Short Reports
Allegaert, Karel
Mian, Paola
Lapillonne, Alexandre
van den Anker, John N.
Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
title Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
title_full Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
title_fullStr Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
title_full_unstemmed Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
title_short Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
title_sort maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303200/
https://www.ncbi.nlm.nih.gov/pubmed/30300944
http://dx.doi.org/10.1111/bcp.13778
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