Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essential gene for the survival of a subset of cancer c...

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Detalles Bibliográficos
Autores principales: Gannon, Hugh S., Zou, Tao, Kiessling, Michael K., Gao, Galen F., Cai, Diana, Choi, Peter S., Ivan, Alexandru P., Buchumenski, Ilana, Berger, Ashton C., Goldstein, Jonathan T., Cherniack, Andrew D., Vazquez, Francisca, Tsherniak, Aviad, Levanon, Erez Y., Hahn, William C., Meyerson, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303303/
https://www.ncbi.nlm.nih.gov/pubmed/30575730
http://dx.doi.org/10.1038/s41467-018-07824-4

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