Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease

In response to acute loss of the Ulp2 SUMO-specific protease, yeast become disomic for chromosome I (ChrI) and ChrXII. Here we report that ChrI disomy, which creates an adaptive advantage in part by increasing the dosage of the Ccr4 deadenylase, was eliminated by extended passaging. Loss of aneuploi...

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Detalles Bibliográficos
Autores principales: Ryu, Hong-Yeoul, López-Giráldez, Francesc, Knight, James, Hwang, Soo Seok, Renner, Christina, Kreft, Stefan G., Hochstrasser, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303320/
https://www.ncbi.nlm.nih.gov/pubmed/30575729
http://dx.doi.org/10.1038/s41467-018-07836-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303320/
https://www.ncbi.nlm.nih.gov/pubmed/30575729
http://dx.doi.org/10.1038/s41467-018-07836-0

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