Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

The precise time when the viral reservoir is seeded during acute HIV-1 infection remains unclear. We previously demonstrated that the viral reservoir was seeded by day 3 following SIVmac251 infection in rhesus monkeys. Here we report the impact of initiating ART on day 0 (6 h), 1, 2, or 3 following...

Descripción completa

Detalles Bibliográficos
Autores principales: Whitney, James B., Lim, So-Yon, Osuna, Christa E., Kublin, Jessica L., Chen, Elsa, Yoon, Gyeol, Liu, Po-Ting, Abbink, Peter, Borducci, Erica N., Hill, Alison, Lewis, Mark G., Geleziunas, Romas, Robb, Merlin L., Michael, Nelson L., Barouch, Dan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303321/
https://www.ncbi.nlm.nih.gov/pubmed/30575753
http://dx.doi.org/10.1038/s41467-018-07881-9
_version_ 1783382154085924864
author Whitney, James B.
Lim, So-Yon
Osuna, Christa E.
Kublin, Jessica L.
Chen, Elsa
Yoon, Gyeol
Liu, Po-Ting
Abbink, Peter
Borducci, Erica N.
Hill, Alison
Lewis, Mark G.
Geleziunas, Romas
Robb, Merlin L.
Michael, Nelson L.
Barouch, Dan H.
author_facet Whitney, James B.
Lim, So-Yon
Osuna, Christa E.
Kublin, Jessica L.
Chen, Elsa
Yoon, Gyeol
Liu, Po-Ting
Abbink, Peter
Borducci, Erica N.
Hill, Alison
Lewis, Mark G.
Geleziunas, Romas
Robb, Merlin L.
Michael, Nelson L.
Barouch, Dan H.
author_sort Whitney, James B.
collection PubMed
description The precise time when the viral reservoir is seeded during acute HIV-1 infection remains unclear. We previously demonstrated that the viral reservoir was seeded by day 3 following SIVmac251 infection in rhesus monkeys. Here we report the impact of initiating ART on day 0 (6 h), 1, 2, or 3 following intrarectal SIVmac251 infection in 20 rhesus monkeys (N = 5/group). After 6 months of daily suppressive ART, antiretroviral drugs were discontinued, and viral rebound was monitored. 0% (0 of 5), 20% (1 of 5), 60% (3 of 5), and 100% (5 of 5) of animals that initiated ART on days 0 (6 h), 1, 2, or 3, respectively, showed viral rebound following ART discontinuation and correlated with integrated viral DNA in lymph node CD4+ T cells. These data demonstrate that the viral reservoir is seeded within the first few days of infection and that early ART initiation limits the viral reservoir.
format Online
Article
Text
id pubmed-6303321
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63033212018-12-23 Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy Whitney, James B. Lim, So-Yon Osuna, Christa E. Kublin, Jessica L. Chen, Elsa Yoon, Gyeol Liu, Po-Ting Abbink, Peter Borducci, Erica N. Hill, Alison Lewis, Mark G. Geleziunas, Romas Robb, Merlin L. Michael, Nelson L. Barouch, Dan H. Nat Commun Article The precise time when the viral reservoir is seeded during acute HIV-1 infection remains unclear. We previously demonstrated that the viral reservoir was seeded by day 3 following SIVmac251 infection in rhesus monkeys. Here we report the impact of initiating ART on day 0 (6 h), 1, 2, or 3 following intrarectal SIVmac251 infection in 20 rhesus monkeys (N = 5/group). After 6 months of daily suppressive ART, antiretroviral drugs were discontinued, and viral rebound was monitored. 0% (0 of 5), 20% (1 of 5), 60% (3 of 5), and 100% (5 of 5) of animals that initiated ART on days 0 (6 h), 1, 2, or 3, respectively, showed viral rebound following ART discontinuation and correlated with integrated viral DNA in lymph node CD4+ T cells. These data demonstrate that the viral reservoir is seeded within the first few days of infection and that early ART initiation limits the viral reservoir. Nature Publishing Group UK 2018-12-21 /pmc/articles/PMC6303321/ /pubmed/30575753 http://dx.doi.org/10.1038/s41467-018-07881-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Whitney, James B.
Lim, So-Yon
Osuna, Christa E.
Kublin, Jessica L.
Chen, Elsa
Yoon, Gyeol
Liu, Po-Ting
Abbink, Peter
Borducci, Erica N.
Hill, Alison
Lewis, Mark G.
Geleziunas, Romas
Robb, Merlin L.
Michael, Nelson L.
Barouch, Dan H.
Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_full Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_fullStr Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_full_unstemmed Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_short Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
title_sort prevention of sivmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303321/
https://www.ncbi.nlm.nih.gov/pubmed/30575753
http://dx.doi.org/10.1038/s41467-018-07881-9
work_keys_str_mv AT whitneyjamesb preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT limsoyon preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT osunachristae preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT kublinjessical preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT chenelsa preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT yoongyeol preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT liupoting preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT abbinkpeter preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT borduccierican preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT hillalison preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT lewismarkg preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT geleziunasromas preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT robbmerlinl preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT michaelnelsonl preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy
AT barouchdanh preventionofsivmac251reservoirseedinginrhesusmonkeysbyearlyantiretroviraltherapy

Ejemplares similares