Loss of Phd2 cooperates with BRAF(V600E) to drive melanomagenesis

Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor. However, the role of PHD2 in tumor initiation remains controversial. We find that during the transition of human nevi to melanoma, the expression of PHD2 protein is significantly decreased and lower expression PHD2 in m...

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Detalles Bibliográficos
Autores principales: Liu, Shujing, Zhang, Gao, Guo, Jianping, Chen, Xiang, Lei, Jingce, Ze, Kan, Dong, Liyun, Dai, Xiangpeng, Gao, Yang, Song, Daisheng, Ecker, Brett L., Yang, Ruifeng, Feltcher, Caitlin, Peng, Kai, Feng, Cheng, Chen, Hui, Lee, Rebecca X., Kerestes, Heddy, Niu, Jingwen, Kumar, Suresh, Xu, Weiting, Zhang, Jie, Wei, Zhi, Martin, James S., Liu, Xiaoming, Mills, Gordon, Lu, Yiling, Guo, Wei, Sun, Lunquan, Zhang, Lin, Weeraratna, Ashani, Herlyn, Meenhard, Wei, Wenyi, Lee, Frank S., Xu, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303344/
https://www.ncbi.nlm.nih.gov/pubmed/30575721
http://dx.doi.org/10.1038/s41467-018-07126-9

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