Ezh2 programs T(FH) differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

Ezh2 is an histone methyltransferase (HMT) that catalyzes H3K27me3 and functions in T(H)1, T(H)2, and Treg cells primarily via HMT activity. Here we show that Ezh2 ablation impairs T follicular helper (T(FH)) cell differentiation and activation of the T(FH) transcription program. In T(FH) cells, mos...

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Detalles Bibliográficos
Autores principales: Li, Fengyin, Zeng, Zhouhao, Xing, Shaojun, Gullicksrud, Jodi A., Shan, Qiang, Choi, Jinyong, Badovinac, Vladimir P., Crotty, Shane, Peng, Weiqun, Xue, Hai-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303346/
https://www.ncbi.nlm.nih.gov/pubmed/30575739
http://dx.doi.org/10.1038/s41467-018-07853-z

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