Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent A...

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Autores principales: Ni, Dalong, Jiang, Dawei, Kutyreff, Christopher J., Lai, Jianhao, Yan, Yongjun, Barnhart, Todd E., Yu, Bo, Im, Hyung-Jun, Kang, Lei, Cho, Steve Y., Liu, Zhaofei, Huang, Peng, Engle, Jonathan W., Cai, Weibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303396/
https://www.ncbi.nlm.nih.gov/pubmed/30575745
http://dx.doi.org/10.1038/s41467-018-07890-8
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author Ni, Dalong
Jiang, Dawei
Kutyreff, Christopher J.
Lai, Jianhao
Yan, Yongjun
Barnhart, Todd E.
Yu, Bo
Im, Hyung-Jun
Kang, Lei
Cho, Steve Y.
Liu, Zhaofei
Huang, Peng
Engle, Jonathan W.
Cai, Weibo
author_facet Ni, Dalong
Jiang, Dawei
Kutyreff, Christopher J.
Lai, Jianhao
Yan, Yongjun
Barnhart, Todd E.
Yu, Bo
Im, Hyung-Jun
Kang, Lei
Cho, Steve Y.
Liu, Zhaofei
Huang, Peng
Engle, Jonathan W.
Cai, Weibo
author_sort Ni, Dalong
collection PubMed
description Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with (68)Ga-EDTA, serum tests, kidney tissue staining, and biomarkers detection in the kidneys. The protective effect of POM nanoclusters against AKI in living animals suggests exploring their use for the treatment of AKI patients, as well as patients with other ROS-related diseases.
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spelling pubmed-63033962018-12-23 Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice Ni, Dalong Jiang, Dawei Kutyreff, Christopher J. Lai, Jianhao Yan, Yongjun Barnhart, Todd E. Yu, Bo Im, Hyung-Jun Kang, Lei Cho, Steve Y. Liu, Zhaofei Huang, Peng Engle, Jonathan W. Cai, Weibo Nat Commun Article Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with (68)Ga-EDTA, serum tests, kidney tissue staining, and biomarkers detection in the kidneys. The protective effect of POM nanoclusters against AKI in living animals suggests exploring their use for the treatment of AKI patients, as well as patients with other ROS-related diseases. Nature Publishing Group UK 2018-12-21 /pmc/articles/PMC6303396/ /pubmed/30575745 http://dx.doi.org/10.1038/s41467-018-07890-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ni, Dalong
Jiang, Dawei
Kutyreff, Christopher J.
Lai, Jianhao
Yan, Yongjun
Barnhart, Todd E.
Yu, Bo
Im, Hyung-Jun
Kang, Lei
Cho, Steve Y.
Liu, Zhaofei
Huang, Peng
Engle, Jonathan W.
Cai, Weibo
Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_full Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_fullStr Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_full_unstemmed Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_short Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_sort molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303396/
https://www.ncbi.nlm.nih.gov/pubmed/30575745
http://dx.doi.org/10.1038/s41467-018-07890-8
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