Impaired immune surveillance accelerates accumulation of senescent cells and aging

Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, preventing their propagation in tissues. However, senescent cells accumulate in tissues in advanced age, where they might promote tissue degeneration and malignant transformation. The extent of immune-sy...

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Detalles Bibliográficos
Autores principales: Ovadya, Yossi, Landsberger, Tomer, Leins, Hanna, Vadai, Ezra, Gal, Hilah, Biran, Anat, Yosef, Reut, Sagiv, Adi, Agrawal, Amit, Shapira, Alon, Windheim, Joseph, Tsoory, Michael, Schirmbeck, Reinhold, Amit, Ido, Geiger, Hartmut, Krizhanovsky, Valery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303397/
https://www.ncbi.nlm.nih.gov/pubmed/30575733
http://dx.doi.org/10.1038/s41467-018-07825-3

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