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Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models

BACKGROUND: Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis. OBJECTIVE: The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models. METHODS: In formaldeh...

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Autores principales: Sharma, Himanshu, Chauhan, Prerna, Singh, Surender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303416/
https://www.ncbi.nlm.nih.gov/pubmed/30591891
http://dx.doi.org/10.1016/j.imr.2018.08.002
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author Sharma, Himanshu
Chauhan, Prerna
Singh, Surender
author_facet Sharma, Himanshu
Chauhan, Prerna
Singh, Surender
author_sort Sharma, Himanshu
collection PubMed
description BACKGROUND: Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis. OBJECTIVE: The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models. METHODS: In formaldehyde model, sub-plantar administration of 0.1 ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six groups as follows: normal control, disease control, indomethacin group (3 mg/kg, p.o.) and three groups, treated with 50, 100 and 200 mg/kg CCHE (p.o.). Joint diameter was measured, and ankle joints were collected for MDA and GSH measurements. In complete Freund's adjuvant (CFA)-induced arthritis model, CFA was injected into the sub-plantar surface of the right hind paw in rats. Joint diameter was measured, and serum TNF-α and IL-1β were measured. Histopathological and immunohistochemical analyses were also performed. RESULTS: CCHE treatment significantly (p < 0.01) reduced MDA levels and joint swelling in a concentration-dependent manner in rats with formaldehyde-induced arthritis, in which GSH levels were elevated (p < 0.01). In rats with CFA-induced arthritis, CCHE treatment significantly reduced joint swelling as well as IL-1β and TNF-α levels (p < 0.01). TNF-α receptor expression was decreased in rats treated with indomethacin or CCHE. CONCLUSION: Based on these findings, it can be concluded that C. cassia possesses anti-arthritic properties.
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spelling pubmed-63034162018-12-27 Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models Sharma, Himanshu Chauhan, Prerna Singh, Surender Integr Med Res Original Article BACKGROUND: Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis. OBJECTIVE: The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models. METHODS: In formaldehyde model, sub-plantar administration of 0.1 ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six groups as follows: normal control, disease control, indomethacin group (3 mg/kg, p.o.) and three groups, treated with 50, 100 and 200 mg/kg CCHE (p.o.). Joint diameter was measured, and ankle joints were collected for MDA and GSH measurements. In complete Freund's adjuvant (CFA)-induced arthritis model, CFA was injected into the sub-plantar surface of the right hind paw in rats. Joint diameter was measured, and serum TNF-α and IL-1β were measured. Histopathological and immunohistochemical analyses were also performed. RESULTS: CCHE treatment significantly (p < 0.01) reduced MDA levels and joint swelling in a concentration-dependent manner in rats with formaldehyde-induced arthritis, in which GSH levels were elevated (p < 0.01). In rats with CFA-induced arthritis, CCHE treatment significantly reduced joint swelling as well as IL-1β and TNF-α levels (p < 0.01). TNF-α receptor expression was decreased in rats treated with indomethacin or CCHE. CONCLUSION: Based on these findings, it can be concluded that C. cassia possesses anti-arthritic properties. Elsevier 2018-12 2018-08-10 /pmc/articles/PMC6303416/ /pubmed/30591891 http://dx.doi.org/10.1016/j.imr.2018.08.002 Text en © 2018 Korea Institute of Oriental Medicine. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Sharma, Himanshu
Chauhan, Prerna
Singh, Surender
Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models
title Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models
title_full Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models
title_fullStr Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models
title_full_unstemmed Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models
title_short Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models
title_sort evaluation of the anti-arthritic activity of cinnamomum cassia bark extract in experimental models
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303416/
https://www.ncbi.nlm.nih.gov/pubmed/30591891
http://dx.doi.org/10.1016/j.imr.2018.08.002
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