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Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review

Flagellar navigation along the genital tract of male and female in spermatozoa is accomplished through a number of biological, physiological, biochemical, and electrophysiological alterations in spermatozoa. These alterations are highly precise, dynamic, and regulated through a number of ion channel...

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Autores principales: Kumar, Akshay, Mishra, Abhishek Kumar, Swain, Dilip Kumar, Singh, Vijay, Yadav, Sarvajeet, Saxena, Atul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303503/
https://www.ncbi.nlm.nih.gov/pubmed/30587898
http://dx.doi.org/10.14202/vetworld.2018.1618-1623
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author Kumar, Akshay
Mishra, Abhishek Kumar
Swain, Dilip Kumar
Singh, Vijay
Yadav, Sarvajeet
Saxena, Atul
author_facet Kumar, Akshay
Mishra, Abhishek Kumar
Swain, Dilip Kumar
Singh, Vijay
Yadav, Sarvajeet
Saxena, Atul
author_sort Kumar, Akshay
collection PubMed
description Flagellar navigation along the genital tract of male and female in spermatozoa is accomplished through a number of biological, physiological, biochemical, and electrophysiological alterations in spermatozoa. These alterations are highly precise, dynamic, and regulated through a number of ion channels along with their associated pathways. Beating of flagella along with intracellular metabolism of spermatozoa is associated with fluxing of Ca++ as well as release of Ca++ from different sources. Calcium fluxing through the spermatozoa is mediated through sperm-specific calcium channel and also through transient receptor potential (TRP) channels which are diversified multifamily of ion channels which are activated through a number of extracellular agents such as pH, temperature, chemicals, and pathogens. Research has shown the dynamic role of TRP channels in regulating sperm functions such as sperm chemotaxis, rheotaxis, thermotaxis, and eventually fertilization. Diversified forms of TRP and their involvement in regulation of sperm function opens new horizons of understanding of the sperm function and, in specific, issues related to infertility. This mini-review is an attempt to draw some insights into the action of TRP channels in regulating sperm fertility competence through both calcium-dependent and calcium-independent mechanisms.
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spelling pubmed-63035032018-12-26 Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review Kumar, Akshay Mishra, Abhishek Kumar Swain, Dilip Kumar Singh, Vijay Yadav, Sarvajeet Saxena, Atul Vet World Review Article Flagellar navigation along the genital tract of male and female in spermatozoa is accomplished through a number of biological, physiological, biochemical, and electrophysiological alterations in spermatozoa. These alterations are highly precise, dynamic, and regulated through a number of ion channels along with their associated pathways. Beating of flagella along with intracellular metabolism of spermatozoa is associated with fluxing of Ca++ as well as release of Ca++ from different sources. Calcium fluxing through the spermatozoa is mediated through sperm-specific calcium channel and also through transient receptor potential (TRP) channels which are diversified multifamily of ion channels which are activated through a number of extracellular agents such as pH, temperature, chemicals, and pathogens. Research has shown the dynamic role of TRP channels in regulating sperm functions such as sperm chemotaxis, rheotaxis, thermotaxis, and eventually fertilization. Diversified forms of TRP and their involvement in regulation of sperm function opens new horizons of understanding of the sperm function and, in specific, issues related to infertility. This mini-review is an attempt to draw some insights into the action of TRP channels in regulating sperm fertility competence through both calcium-dependent and calcium-independent mechanisms. Veterinary World 2018-11 2018-11-23 /pmc/articles/PMC6303503/ /pubmed/30587898 http://dx.doi.org/10.14202/vetworld.2018.1618-1623 Text en Copyright: © Kumar, et al. http://creativecommons.org/licenses/by/4.0 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review Article
Kumar, Akshay
Mishra, Abhishek Kumar
Swain, Dilip Kumar
Singh, Vijay
Yadav, Sarvajeet
Saxena, Atul
Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review
title Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review
title_full Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review
title_fullStr Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review
title_full_unstemmed Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review
title_short Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review
title_sort role of transient receptor potential channels in regulating spermatozoa functions: a mini-review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303503/
https://www.ncbi.nlm.nih.gov/pubmed/30587898
http://dx.doi.org/10.14202/vetworld.2018.1618-1623
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