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Wave reflections and global arterial compliance during normal human pregnancy

Profound changes occur in the maternal circulation during pregnancy. Routine measures of arterial function – central systolic pressure (CSP) and augmentation index (AIx) – decline during normal human pregnancy. The objectives of this study were twofold: (1) explore wave reflection indices besides CS...

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Autores principales: Rodriguez, Claudia, Chi, Yueh‐Yun, Chiu, Kuei‐Hsun, Zhai, Xiaoman, Lingis, Melissa, Williams, Robert Stan, Rhoton‐Vlasak, Alice, Nichols, Wilmer W., Petersen, John W., Segal, Mark S., Conrad, Kirk P., Mohandas, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303533/
https://www.ncbi.nlm.nih.gov/pubmed/30578623
http://dx.doi.org/10.14814/phy2.13947
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author Rodriguez, Claudia
Chi, Yueh‐Yun
Chiu, Kuei‐Hsun
Zhai, Xiaoman
Lingis, Melissa
Williams, Robert Stan
Rhoton‐Vlasak, Alice
Nichols, Wilmer W.
Petersen, John W.
Segal, Mark S.
Conrad, Kirk P.
Mohandas, Rajesh
author_facet Rodriguez, Claudia
Chi, Yueh‐Yun
Chiu, Kuei‐Hsun
Zhai, Xiaoman
Lingis, Melissa
Williams, Robert Stan
Rhoton‐Vlasak, Alice
Nichols, Wilmer W.
Petersen, John W.
Segal, Mark S.
Conrad, Kirk P.
Mohandas, Rajesh
author_sort Rodriguez, Claudia
collection PubMed
description Profound changes occur in the maternal circulation during pregnancy. Routine measures of arterial function – central systolic pressure (CSP) and augmentation index (AIx) – decline during normal human pregnancy. The objectives of this study were twofold: (1) explore wave reflection indices besides CSP and AIx that are not routinely reported, if at all, during normal human pregnancy; and (2) compare wave reflection indices and global arterial compliance (gAC) obtained from carotid artery pressure waveforms (CAPW) as a surrogate for aortic pressure waveforms (AOPW) versus AOPW synthesized from radial artery pressure waveforms (RAPW) using a generalized transfer function. To our knowledge, a comparison of these two methods has not been previously evaluated in the context of pregnancy. Ten healthy women with normal singleton pregnancies were studied using applanation tonometry (SphygmoCor) at pre‐conception, and then during 10–12 and 33–35 gestational weeks. CSP and AIx declined, and gAC increased during pregnancy as previously reported. As a consequence of the rise in gAC, the return of reflected waves of lesser magnitude from peripheral reflection sites to the aorta was delayed that, in turn, reduced systolic duration of reflected waves, augmentation index, central systolic pressure, LV wasted energy due to reflected waves, and increased brachial‐central pulse pressure. For several wave reflection indices, those derived from CAPW as a surrogate for AOPW versus RAPW using a generalized transfer function registered greater gestational increases of arterial compliance. This discordance may reflect imprecision of the generalized transfer function for some waveform parameters, though potential divergence of carotid artery and aortic pressure waveforms during pregnancy cannot be excluded.
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spelling pubmed-63035332018-12-31 Wave reflections and global arterial compliance during normal human pregnancy Rodriguez, Claudia Chi, Yueh‐Yun Chiu, Kuei‐Hsun Zhai, Xiaoman Lingis, Melissa Williams, Robert Stan Rhoton‐Vlasak, Alice Nichols, Wilmer W. Petersen, John W. Segal, Mark S. Conrad, Kirk P. Mohandas, Rajesh Physiol Rep Original Research Profound changes occur in the maternal circulation during pregnancy. Routine measures of arterial function – central systolic pressure (CSP) and augmentation index (AIx) – decline during normal human pregnancy. The objectives of this study were twofold: (1) explore wave reflection indices besides CSP and AIx that are not routinely reported, if at all, during normal human pregnancy; and (2) compare wave reflection indices and global arterial compliance (gAC) obtained from carotid artery pressure waveforms (CAPW) as a surrogate for aortic pressure waveforms (AOPW) versus AOPW synthesized from radial artery pressure waveforms (RAPW) using a generalized transfer function. To our knowledge, a comparison of these two methods has not been previously evaluated in the context of pregnancy. Ten healthy women with normal singleton pregnancies were studied using applanation tonometry (SphygmoCor) at pre‐conception, and then during 10–12 and 33–35 gestational weeks. CSP and AIx declined, and gAC increased during pregnancy as previously reported. As a consequence of the rise in gAC, the return of reflected waves of lesser magnitude from peripheral reflection sites to the aorta was delayed that, in turn, reduced systolic duration of reflected waves, augmentation index, central systolic pressure, LV wasted energy due to reflected waves, and increased brachial‐central pulse pressure. For several wave reflection indices, those derived from CAPW as a surrogate for AOPW versus RAPW using a generalized transfer function registered greater gestational increases of arterial compliance. This discordance may reflect imprecision of the generalized transfer function for some waveform parameters, though potential divergence of carotid artery and aortic pressure waveforms during pregnancy cannot be excluded. John Wiley and Sons Inc. 2018-12-21 /pmc/articles/PMC6303533/ /pubmed/30578623 http://dx.doi.org/10.14814/phy2.13947 Text en © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Rodriguez, Claudia
Chi, Yueh‐Yun
Chiu, Kuei‐Hsun
Zhai, Xiaoman
Lingis, Melissa
Williams, Robert Stan
Rhoton‐Vlasak, Alice
Nichols, Wilmer W.
Petersen, John W.
Segal, Mark S.
Conrad, Kirk P.
Mohandas, Rajesh
Wave reflections and global arterial compliance during normal human pregnancy
title Wave reflections and global arterial compliance during normal human pregnancy
title_full Wave reflections and global arterial compliance during normal human pregnancy
title_fullStr Wave reflections and global arterial compliance during normal human pregnancy
title_full_unstemmed Wave reflections and global arterial compliance during normal human pregnancy
title_short Wave reflections and global arterial compliance during normal human pregnancy
title_sort wave reflections and global arterial compliance during normal human pregnancy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303533/
https://www.ncbi.nlm.nih.gov/pubmed/30578623
http://dx.doi.org/10.14814/phy2.13947
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