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Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming

BACKGROUND: Both human and mouse fibroblasts can be reprogrammed to pluripotency with Oct4, Sox2, Klf4, and c-Myc (OSKM) transcription factors. While both systems generate pluripotency, human reprogramming takes considerably longer than mouse. RESULTS: To assess additional similarities and differenc...

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Detalles Bibliográficos
Autores principales:	Fu, Kai, Chronis, Constantinos, Soufi, Abdenour, Bonora, Giancarlo, Edwards, Miguel, Smale, Stephen T., Zaret, Kenneth S., Plath, Kathrin, Pellegrini, Matteo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303873/ https://www.ncbi.nlm.nih.gov/pubmed/30577748 http://dx.doi.org/10.1186/s12864-018-5326-1

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