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Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts

Pleurotus ferulae is an edible and medicinal mushroom with various bioactivities. Here, the ethanol extracts of wild and cultivated P. ferulae (PFEE-W and PFEE-C) and their subfractions including petroleum ether (Pe-W/Pe-C), ethyl acetate (Ea-W/Ea-C) and n-butanol (Ba-W/Ba-C) were prepared to evalua...

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Autores principales: Yang, Yi, Fu, Changshuang, Zhou, Fangfang, Luo, Xiaoyu, Li, Jinyu, Zhao, Jun, He, Jiang, Li, Xiaoqin, Li, Jinyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304266/
https://www.ncbi.nlm.nih.gov/pubmed/30595979
http://dx.doi.org/10.7717/peerj.6097
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author Yang, Yi
Fu, Changshuang
Zhou, Fangfang
Luo, Xiaoyu
Li, Jinyu
Zhao, Jun
He, Jiang
Li, Xiaoqin
Li, Jinyao
author_facet Yang, Yi
Fu, Changshuang
Zhou, Fangfang
Luo, Xiaoyu
Li, Jinyu
Zhao, Jun
He, Jiang
Li, Xiaoqin
Li, Jinyao
author_sort Yang, Yi
collection PubMed
description Pleurotus ferulae is an edible and medicinal mushroom with various bioactivities. Here, the ethanol extracts of wild and cultivated P. ferulae (PFEE-W and PFEE-C) and their subfractions including petroleum ether (Pe-W/Pe-C), ethyl acetate (Ea-W/Ea-C) and n-butanol (Ba-W/Ba-C) were prepared to evaluate their antioxidant and antitumor activities. Both PFEE-W and PFEE-C show the antioxidant activity and PFEE-W is stronger than PFEE-C. The antioxidant activities of their subfractions are in the following order: Ea > Ba > Pe. Moreover, PFEE-W and PFEE-C significantly inhibit the proliferation of murine melanoma B16 cells, human esophageal cancer Eca-109 cells, human gastric cancer BGC823 cells and human cervical cancer HeLa cells through induction of apoptosis, which partially mediated by reactive oxygen species. The antitumor activities of their subfractions are in the following order: Ea ≥ Pe > Ba. Pe-W shows higher antitumor activity compared with Pe-C, which might be correlated with the difference of their components identified by gas chromatography-mass spectrometry. These results suggest that both wild and cultivated P. ferulae have antioxidant and antitumor activities, and cultivated P. ferulae could be used to replace wild one in some functions.
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spelling pubmed-63042662018-12-28 Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts Yang, Yi Fu, Changshuang Zhou, Fangfang Luo, Xiaoyu Li, Jinyu Zhao, Jun He, Jiang Li, Xiaoqin Li, Jinyao PeerJ Biochemistry Pleurotus ferulae is an edible and medicinal mushroom with various bioactivities. Here, the ethanol extracts of wild and cultivated P. ferulae (PFEE-W and PFEE-C) and their subfractions including petroleum ether (Pe-W/Pe-C), ethyl acetate (Ea-W/Ea-C) and n-butanol (Ba-W/Ba-C) were prepared to evaluate their antioxidant and antitumor activities. Both PFEE-W and PFEE-C show the antioxidant activity and PFEE-W is stronger than PFEE-C. The antioxidant activities of their subfractions are in the following order: Ea > Ba > Pe. Moreover, PFEE-W and PFEE-C significantly inhibit the proliferation of murine melanoma B16 cells, human esophageal cancer Eca-109 cells, human gastric cancer BGC823 cells and human cervical cancer HeLa cells through induction of apoptosis, which partially mediated by reactive oxygen species. The antitumor activities of their subfractions are in the following order: Ea ≥ Pe > Ba. Pe-W shows higher antitumor activity compared with Pe-C, which might be correlated with the difference of their components identified by gas chromatography-mass spectrometry. These results suggest that both wild and cultivated P. ferulae have antioxidant and antitumor activities, and cultivated P. ferulae could be used to replace wild one in some functions. PeerJ Inc. 2018-12-20 /pmc/articles/PMC6304266/ /pubmed/30595979 http://dx.doi.org/10.7717/peerj.6097 Text en © 2018 Yang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Biochemistry
Yang, Yi
Fu, Changshuang
Zhou, Fangfang
Luo, Xiaoyu
Li, Jinyu
Zhao, Jun
He, Jiang
Li, Xiaoqin
Li, Jinyao
Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts
title Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts
title_full Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts
title_fullStr Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts
title_full_unstemmed Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts
title_short Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts
title_sort chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated pleurotus ferulae ethanol extracts
topic Biochemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304266/
https://www.ncbi.nlm.nih.gov/pubmed/30595979
http://dx.doi.org/10.7717/peerj.6097
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