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Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses

BACKGROUND: The relationship between obesity and risk of complications described during the 2009 influenza pandemic is poorly defined for seasonal influenza and other viral causes of influenza‐like illness (ILI). METHODS: An observational cohort of hospitalized and outpatient participants with ILI w...

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Autores principales: Moser, Joe‐Ann S., Galindo‐Fraga, Arturo, Ortiz‐Hernández, Ana A., Gu, Wenjuan, Hunsberger, Sally, Galán‐Herrera, Juan‐Francisco, Guerrero, María Lourdes, Ruiz‐Palacios, Guillermo M., Beigel, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304312/
https://www.ncbi.nlm.nih.gov/pubmed/30515985
http://dx.doi.org/10.1111/irv.12618
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author Moser, Joe‐Ann S.
Galindo‐Fraga, Arturo
Ortiz‐Hernández, Ana A.
Gu, Wenjuan
Hunsberger, Sally
Galán‐Herrera, Juan‐Francisco
Guerrero, María Lourdes
Ruiz‐Palacios, Guillermo M.
Beigel, John H.
author_facet Moser, Joe‐Ann S.
Galindo‐Fraga, Arturo
Ortiz‐Hernández, Ana A.
Gu, Wenjuan
Hunsberger, Sally
Galán‐Herrera, Juan‐Francisco
Guerrero, María Lourdes
Ruiz‐Palacios, Guillermo M.
Beigel, John H.
author_sort Moser, Joe‐Ann S.
collection PubMed
description BACKGROUND: The relationship between obesity and risk of complications described during the 2009 influenza pandemic is poorly defined for seasonal influenza and other viral causes of influenza‐like illness (ILI). METHODS: An observational cohort of hospitalized and outpatient participants with ILI was conducted in six hospitals in Mexico. Nasopharyngeal swabs were tested for influenza and other common respiratory pathogens. RESULTS: A total of 4778 participants were enrolled in this study and had complete data. A total of 2053 (43.0%) had severe ILI. Seven hundred and seventy‐eight (16.3%) were positive for influenza, 2636 (55.2%) were positive for other viral respiratory pathogens, and 1364 (28.5%) had no respiratory virus isolated. Adults with influenza were more likely to be hospitalized if they were underweight (OR: 5.20), obese (OR: 3.18), or morbidly obese (OR: 18.40) compared to normal‐weight adults. Obese adults with H1N1 had a sixfold increase in odds of hospitalization over H3N2 and B (obese OR: 8.96 vs 1.35, morbidly obese OR: 35.13 vs 5.58, respectively) compared to normal‐weight adults. In adults with coronavirus, metapneumovirus, parainfluenza, and rhinovirus, participants that were underweight (OR: 4.07) and morbidly obese (OR: 2.78) were more likely to be hospitalized as compared to normal‐weight adults. All‐cause influenza‐like illness had a similar but less pronounced association between underweight or morbidly obesity and hospitalization. CONCLUSIONS: There is an increased risk of being hospitalized in adult participants that are underweight or morbidly obese, regardless of their viral pathogen status. Having influenza, however, significantly increases the odds of hospitalization in those who are underweight or morbidly obese.
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spelling pubmed-63043122019-01-04 Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses Moser, Joe‐Ann S. Galindo‐Fraga, Arturo Ortiz‐Hernández, Ana A. Gu, Wenjuan Hunsberger, Sally Galán‐Herrera, Juan‐Francisco Guerrero, María Lourdes Ruiz‐Palacios, Guillermo M. Beigel, John H. Influenza Other Respir Viruses Original Articles BACKGROUND: The relationship between obesity and risk of complications described during the 2009 influenza pandemic is poorly defined for seasonal influenza and other viral causes of influenza‐like illness (ILI). METHODS: An observational cohort of hospitalized and outpatient participants with ILI was conducted in six hospitals in Mexico. Nasopharyngeal swabs were tested for influenza and other common respiratory pathogens. RESULTS: A total of 4778 participants were enrolled in this study and had complete data. A total of 2053 (43.0%) had severe ILI. Seven hundred and seventy‐eight (16.3%) were positive for influenza, 2636 (55.2%) were positive for other viral respiratory pathogens, and 1364 (28.5%) had no respiratory virus isolated. Adults with influenza were more likely to be hospitalized if they were underweight (OR: 5.20), obese (OR: 3.18), or morbidly obese (OR: 18.40) compared to normal‐weight adults. Obese adults with H1N1 had a sixfold increase in odds of hospitalization over H3N2 and B (obese OR: 8.96 vs 1.35, morbidly obese OR: 35.13 vs 5.58, respectively) compared to normal‐weight adults. In adults with coronavirus, metapneumovirus, parainfluenza, and rhinovirus, participants that were underweight (OR: 4.07) and morbidly obese (OR: 2.78) were more likely to be hospitalized as compared to normal‐weight adults. All‐cause influenza‐like illness had a similar but less pronounced association between underweight or morbidly obesity and hospitalization. CONCLUSIONS: There is an increased risk of being hospitalized in adult participants that are underweight or morbidly obese, regardless of their viral pathogen status. Having influenza, however, significantly increases the odds of hospitalization in those who are underweight or morbidly obese. John Wiley and Sons Inc. 2018-12-04 2019-01 /pmc/articles/PMC6304312/ /pubmed/30515985 http://dx.doi.org/10.1111/irv.12618 Text en © 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Moser, Joe‐Ann S.
Galindo‐Fraga, Arturo
Ortiz‐Hernández, Ana A.
Gu, Wenjuan
Hunsberger, Sally
Galán‐Herrera, Juan‐Francisco
Guerrero, María Lourdes
Ruiz‐Palacios, Guillermo M.
Beigel, John H.
Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
title Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
title_full Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
title_fullStr Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
title_full_unstemmed Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
title_short Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
title_sort underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304312/
https://www.ncbi.nlm.nih.gov/pubmed/30515985
http://dx.doi.org/10.1111/irv.12618
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