Genetic Deletion of P2Y(2) Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Proliferation

Chronic lithium administration for the treatment of bipolar disorder leads to nephrogenic diabetes insipidus (NDI), characterized by polyuria, natriuresis, kaliuresis, and collecting duct remodeling and cell proliferation among other features. Previously, using a 2-week lithium-induced NDI model, we...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Riquier-Brison, Anne, Liu, Tao, Huang, Yufeng, Carlson, Noel G., Peti-Peterdi, János, Kishore, Bellamkonda K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304354/
https://www.ncbi.nlm.nih.gov/pubmed/30618788
http://dx.doi.org/10.3389/fphys.2018.01765

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