Cargando…

GRK5 – A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders

Complex aging-triggered disorders are multifactorial programs that comprise a myriad of alterations in interconnected protein networks over a broad range of tissues. It is evident that rather than being randomly organized events, pathophysiologies that possess a strong aging component such as cardio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hendrickx, Jhana O., van Gastel, Jaana, Leysen, Hanne, Santos-Otte, Paula, Premont, Richard T., Martin, Bronwen, Maudsley, Stuart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304357/ https://www.ncbi.nlm.nih.gov/pubmed/30618771 http://dx.doi.org/10.3389/fphar.2018.01484

Ejemplares similares

β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders
por: van Gastel, Jaana, et al.
Publicado: (2018)

G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
por: Leysen, Hanne, et al.
Publicado: (2018)

G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence
por: Santos-Otte, Paula, et al.
Publicado: (2019)

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage
por: van Gastel, Jaana, et al.
Publicado: (2019)

The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease
por: Leysen, Hanne, et al.
Publicado: (2022)

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases
por: Murga, Cristina, et al.
Publicado: (2019)

Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor
por: Wang, Hui-Jing, et al.
Publicado: (2018)

β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation
por: Rodriguez-Serrano, María, et al.
Publicado: (2019)

Hydroxychloroquine attenuates autoimmune hepatitis by suppressing the interaction of GRK2 with PI3K in T lymphocytes
por: Jin, Chao, et al.
Publicado: (2022)

The role of GRK6 in animal models of Parkinson's Disease and L-DOPA treatment
por: Managò, Francesca, et al.
Publicado: (2012)

Imaging of Microglia in Patients with Neurodegenerative Disorders
por: Politis, Marios, et al.
Publicado: (2012)

History of Innate Immunity in Neurodegenerative Disorders
por: McGeer, Patrick L., et al.
Publicado: (2011)

Neurodegenerative disorders: the Glia way forward
por: Barker, Roger A., et al.
Publicado: (2014)

Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells
por: Palikhe, Sailesh, et al.
Publicado: (2019)

Corrigendum: Hydroxychloroquine attenuates autoimmune hepatitis by suppressing the interaction of GRK2 with PI3K in T lymphocytes
por: Jin, Chao, et al.
Publicado: (2023)

GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability
por: He, Minchao, et al.
Publicado: (2016)

Systems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor System
por: Janssens, Jonathan, et al.
Publicado: (2014)

Isoprenaline and salbutamol inhibit pyroptosis and promote mitochondrial biogenesis in arthritic chondrocytes by downregulating β-arrestin and GRK2
por: Ajmal, Iqra, et al.
Publicado: (2022)

Amylin at the interface between metabolic and neurodegenerative disorders
por: Lutz, Thomas A., et al.
Publicado: (2015)

Neuroinflammation as a Common Feature of Neurodegenerative Disorders
por: Guzman-Martinez, Leonardo, et al.
Publicado: (2019)

Pharmacologic Approaches for the Management of Apathy in Neurodegenerative Disorders
por: Bogdan, Anamaria, et al.
Publicado: (2020)

Cannabidiol for neurodegenerative disorders: A comprehensive review
por: Bhunia, Sukanya, et al.
Publicado: (2022)

GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process
por: Maudsley, Stuart, et al.
Publicado: (2023)

Current Drug Repurposing Strategies for Rare Neurodegenerative Disorders
por: Shah, Sweta, et al.
Publicado: (2021)

Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption
por: Siddiqui, Sana, et al.
Publicado: (2017)

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition
por: Maning, Jennifer, et al.
Publicado: (2020)

Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone–Vascular Axis
por: De Maré, Annelies, et al.
Publicado: (2019)

The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light
por: Collingwood, Joanna F., et al.
Publicado: (2014)

MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders
por: Han, Dong, et al.
Publicado: (2020)

Editorial: Current Trends in Medicinal Plant Research and Neurodegenerative Disorders
por: Ayaz, Muhammad, et al.
Publicado: (2022)

Editorial: Natural products as drivers in drug development for neurodegenerative disorders
por: Silva, Joana, et al.
Publicado: (2022)

Editorial: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-Related Diseases: From Bench to Bedside
por: Liu, Yue, et al.
Publicado: (2020)

The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders
por: Wong, Bruce X., et al.
Publicado: (2014)

GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease
por: Leysen, Hanne, et al.
Publicado: (2021)

The glial response to intracerebrally delivered therapies for neurodegenerative disorders: is this a critical issue?
por: Cicchetti, Francesca, et al.
Publicado: (2014)

Editorial: Natural products as drivers in drug development for neurodegenerative disorders, volume II
por: Silva, Joana, et al.
Publicado: (2023)

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.
por: Sorriento, Daniela, et al.
Publicado: (2014)

Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots
por: Reichel, Mona, et al.
Publicado: (2022)

Impairment of Interrelated Iron- and Copper Homeostatic Mechanisms in Brain Contributes to the Pathogenesis of Neurodegenerative Disorders
por: Skjørringe, Tina, et al.
Publicado: (2012)

Mesenchymal Stem Cell-Based Therapy for Lysosomal Storage Diseases and Other Neurodegenerative Disorders
por: Issa, Shaza S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g0v6qbbbb9r7lpmda4rtos4q12