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Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells

The large clostridial glucosylating toxin B (TcdB) is a major virulence factor of the nosocomial pathogen Clostridioides difficile. TcdB inhibits small GTPases by glucosylation leading to impaired downstream signaling. TcdB also possesses a glucosyltransferase independent effect described as pyknosi...

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Detalles Bibliográficos
Autores principales: Junemann, Johannes, Just, Ingo, Gerhard, Ralf, Pich, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304397/
https://www.ncbi.nlm.nih.gov/pubmed/30619164
http://dx.doi.org/10.3389/fmicb.2018.03083