Cargando…

Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells

The large clostridial glucosylating toxin B (TcdB) is a major virulence factor of the nosocomial pathogen Clostridioides difficile. TcdB inhibits small GTPases by glucosylation leading to impaired downstream signaling. TcdB also possesses a glucosyltransferase independent effect described as pyknosi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Junemann, Johannes, Just, Ingo, Gerhard, Ralf, Pich, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304397/ https://www.ncbi.nlm.nih.gov/pubmed/30619164 http://dx.doi.org/10.3389/fmicb.2018.03083

Ejemplares similares

The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
por: Stieglitz, Florian, et al.
Publicado: (2021)

Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018
por: Genth, Harald, et al.
Publicado: (2018)

Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile
por: Mehner-Breitfeld, Denise, et al.
Publicado: (2018)

The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
por: Chung, Soo-Young, et al.
Publicado: (2018)

TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells
por: Stieglitz, Florian, et al.
Publicado: (2022)

Host Immune Responses to Clostridioides difficile: Toxins and Beyond
por: Nibbering, Britt, et al.
Publicado: (2021)

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B
por: Schöttelndreier, Dennis, et al.
Publicado: (2018)

Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells
por: Marquardt, Isabel, et al.
Publicado: (2021)

Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production
por: Hofmann, Julia D., et al.
Publicado: (2018)

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
por: Hussack, Greg, et al.
Publicado: (2023)

Iron Regulation in Clostridioides difficile
por: Berges, Mareike, et al.
Publicado: (2018)

The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB
por: Papatheodorou, Panagiotis, et al.
Publicado: (2021)

The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition
por: Petersen, Lara, et al.
Publicado: (2022)

Rapid visualization of Clostridioides difficile toxins A and B by multiplex RPA combined with CRISPR-Cas12a
por: Jiang, Tong, et al.
Publicado: (2023)

Corrigendum: Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
por: Hussack, Greg, et al.
Publicado: (2023)

Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile
por: Fühner, Viola, et al.
Publicado: (2018)

The prognostic value of toxin B and binary toxin in Clostridioides difficile infection
por: López-Cárdenas, Salvador, et al.
Publicado: (2021)

Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotope-coded protein labeling and LC-MALDI
por: Jochim, Nelli, et al.
Publicado: (2011)

An Update on Clostridioides difficile Binary Toxin
por: Martínez-Meléndez, Adrián, et al.
Publicado: (2022)

Metabolism the Difficile Way: The Key to the Success of the Pathogen Clostridioides difficile
por: Neumann-Schaal, Meina, et al.
Publicado: (2019)

Editorial: Microbial interactions of Clostridioides difficile
por: Goh, Shan, et al.
Publicado: (2023)

Clostridioides difficile Phosphoproteomics Shows an Expansion of Phosphorylated Proteins in Stationary Growth Phase
por: Smits, Wiep Klaas, et al.
Publicado: (2022)

In-Depth Characterization of the Clostridioides difficile Phosphoproteome to Identify Ser/Thr Kinase Substrates
por: Garcia-Garcia, Transito, et al.
Publicado: (2022)

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
por: Genth, Harald, et al.
Publicado: (2016)

Ribotype Classification of Clostridioides difficile Isolates Is Not Predictive of the Amino Acid Sequence Diversity of the Toxin Virulence Factors TcdA and TcdB
por: Li, Zhenghui, et al.
Publicado: (2020)

Clostridioides difficile Toxin A-Induced Wnt/β-Catenin Pathway Inhibition Is Mediated by Rac1 Glucosylation
por: Martins, Conceição S., et al.
Publicado: (2020)

The Cytopathic Effect of Different Toxin Concentrations From Different Clostridioides difficile Sequence Types Strains in Vero Cells
por: Hamo, Zohar, et al.
Publicado: (2021)

The Alternative Sigma Factor SigL Influences Clostridioides difficile Toxin Production, Sporulation, and Cell Surface Properties
por: Clark, Andrew E., et al.
Publicado: (2022)

Consortium of Probiotics Attenuates Colonization of Clostridioides difficile
por: Li, Xianping, et al.
Publicado: (2019)

Thiol Metabolism and Volatile Metabolome of Clostridioides difficile
por: Biwer, Peter, et al.
Publicado: (2022)

Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection
por: Zhu, Duolong, et al.
Publicado: (2018)

Inhibition of Clostridioides difficile Toxins TcdA and TcdB by Ambroxol
por: Heber, Sebastian, et al.
Publicado: (2022)

Clostridiumnovyi’s Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells
por: Schweitzer, Theresa, et al.
Publicado: (2022)

A Metabolic Labeling Strategy for Relative Protein Quantification in Clostridioides difficile
por: Trautwein-Schult, Anke, et al.
Publicado: (2018)

Bacteriophages Contribute to Shaping Clostridioides (Clostridium) difficile Species
por: Fortier, Louis-Charles
Publicado: (2018)

Fecal Microbiota of Toxigenic Clostridioides difficile-Associated Diarrhea
por: Hernández, Marta, et al.
Publicado: (2019)

Gut Dysbiosis and Clostridioides difficile Infection in Neonates and Adults
por: Vasilescu, Iulia-Magdalena, et al.
Publicado: (2022)

Clostridioides difficile minimal nutrient requirements for flagellar motility
por: Schwanbeck, Julian, et al.
Publicado: (2023)

The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses
por: Bassotti, Gabrio, et al.
Publicado: (2020)

Structure and conformational dynamics of Clostridioides difficile toxin A
por: Chen, Baohua, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ovsl40n9kvv3giqvve5teojrro