A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma

Data from human biopsies, in-vitro and in-vivo models, strongly supports the role of thrombin, and its protease-activated receptor (PAR1) in the pathology and progression of glioblastoma (GBM), a high-grade glial tumor. Activation of PAR1 by thrombin stimulates vasogenic edema, tumor adhesion and tu...

Descripción completa

Detalles Bibliográficos
Autores principales: Shavit-Stein, Efrat, Sheinberg, Ehud, Golderman, Valery, Sharabi, Shirley, Wohl, Anton, Gofrit, Shany Guly, Zivli, Zion, Shelestovich, Natalia, Last, David, Guez, David, Daniels, Dianne, Gera, Orna, Feingold, Kate, Itsekson-Hayosh, Zeev, Rosenberg, Nurit, Tamarin, Ilia, Dori, Amir, Maggio, Nicola, Mardor, Yael, Chapman, Joab, Harnof, Sagi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304418/
https://www.ncbi.nlm.nih.gov/pubmed/30619047
http://dx.doi.org/10.3389/fneur.2018.01087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304418/
https://www.ncbi.nlm.nih.gov/pubmed/30619047
http://dx.doi.org/10.3389/fneur.2018.01087

Ejemplares similares