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A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma

Data from human biopsies, in-vitro and in-vivo models, strongly supports the role of thrombin, and its protease-activated receptor (PAR1) in the pathology and progression of glioblastoma (GBM), a high-grade glial tumor. Activation of PAR1 by thrombin stimulates vasogenic edema, tumor adhesion and tu...

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Detalles Bibliográficos
Autores principales:	Shavit-Stein, Efrat, Sheinberg, Ehud, Golderman, Valery, Sharabi, Shirley, Wohl, Anton, Gofrit, Shany Guly, Zivli, Zion, Shelestovich, Natalia, Last, David, Guez, David, Daniels, Dianne, Gera, Orna, Feingold, Kate, Itsekson-Hayosh, Zeev, Rosenberg, Nurit, Tamarin, Ilia, Dori, Amir, Maggio, Nicola, Mardor, Yael, Chapman, Joab, Harnof, Sagi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304418/ https://www.ncbi.nlm.nih.gov/pubmed/30619047 http://dx.doi.org/10.3389/fneur.2018.01087

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