Perylenequinones from an endophytic Alternaria sp. of Pinus ponderosa

The differential solvent extraction and further purification of fractions of endophytic Alternaria sp. isolated from Pinus ponderosa led to the isolation of further two perylenequinone compounds as 3,6,6a,9,10-pentahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene (1) and 3,6,6a,7,10-penta...

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Detalles Bibliográficos
Autores principales: Tantry, Mudasir A., Idris, Ahmed S., Williamson, John S., Shafi, Tasfi, Dar, Jehangir S., Malik, Tauseef A., Ganai, Bashir A., Shawl, Abdul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304448/
https://www.ncbi.nlm.nih.gov/pubmed/30603688
http://dx.doi.org/10.1016/j.heliyon.2018.e01046
Descripción
Sumario:The differential solvent extraction and further purification of fractions of endophytic Alternaria sp. isolated from Pinus ponderosa led to the isolation of further two perylenequinone compounds as 3,6,6a,9,10-pentahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene (1) and 3,6,6a,7,10-pentahydroxy-4,9-dioxo-4,5,6,6a,6b,7,8,9-octahydroperylene (2). Structure of compounds 1–2 was determined on the basis of detailed spectroscopic analysis, as well as by comparison with literature reports. The antimicrobial, antileismanial, antimalarial and cytotoxic activities of compound 1 and 2 were evaluated.

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