Hyperinsulinemic hypoglycemia subtype glucokinase V91L mutant induces necrosis in β-cells via ATP depletion

Hyperinsulinemic hypoglycemia subtype glucokinase (GCK-HH) is caused by an activating mutation in glucokinase (GCK) and has been shown to increase β-cell death. However, the mechanism of β-cell death in GCK-HH remains poorly understood. Here, we expressed the GCK-HH V91L GCK mutant in INS-1 832/13 c...

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Detalles Bibliográficos
Autores principales: Lu, Brian, Tonne, Jason M., Munoz-Gomez, Miguel, Ikeda, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304456/
https://www.ncbi.nlm.nih.gov/pubmed/30623114
http://dx.doi.org/10.1016/j.bbrep.2018.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304456/
https://www.ncbi.nlm.nih.gov/pubmed/30623114
http://dx.doi.org/10.1016/j.bbrep.2018.12.002

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