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Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease
BACKGROUND: We aimed to investigate how altered intrinsic connectivity networks (ICNs) affect pathologic changes of Alzheimer's disease (AD) at a network-based level. METHODS: Thirty normal controls (NCs), 23 patients with AD-mild cognitive impairment (MCI), and 20 patients with AD-dementia wer...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304529/ https://www.ncbi.nlm.nih.gov/pubmed/30627575 http://dx.doi.org/10.1155/2018/8565620 |
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author | Chang, Ya-Ting Huang, Chi-Wei Chang, Wen-Neng Lee, Jun-Jun Chang, Chiung-Chih |
author_facet | Chang, Ya-Ting Huang, Chi-Wei Chang, Wen-Neng Lee, Jun-Jun Chang, Chiung-Chih |
author_sort | Chang, Ya-Ting |
collection | PubMed |
description | BACKGROUND: We aimed to investigate how altered intrinsic connectivity networks (ICNs) affect pathologic changes of Alzheimer's disease (AD) at a network-based level. METHODS: Thirty normal controls (NCs), 23 patients with AD-mild cognitive impairment (MCI), and 20 patients with AD-dementia were enrolled. We compared the organization of grey matter structural covariance and functional connectivity in ICNs between NCs and all AD patients who were amyloid β (Aβ)-positive. We further used seed-based interregional covariance analysis to compare structural and Aβ plaque covariance in default mode network (DMN) between AD-MCI and AD-dementia groups. RESULTS: The patients with AD had increased functional interregional covariance among the regions of the ICN anchored to dorsal caudate (DC) seeds compared to the NCs. The increased connectivity was associated with extended patterns of reduced Aβ plaque covariance in the AD-dementia group compared to the AD-MCI group within the striatal network anchored to DC seeds. Patterns of lower Aβ plaque covariance in the AD-dementia group compared to the AD-MCI group were more extended within the network anchored to DC seeds than within the DMN, which was undergoing functional failure in the patients with AD. Significant decreased structural covariance in the AD-dementia group compared to the AD-MCI group was more extended in the DMN during functional failure. CONCLUSIONS: Functional connectivity in ICNs affects the topographic spread of molecular pathologies. The temporal trajectory of pathologic alterations can be well demonstrated by pathologic covariance comparisons between different clinical stages. Pathologic covariance can provide critical support to pathologic interactions at network and molecular levels. |
format | Online Article Text |
id | pubmed-6304529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63045292019-01-09 Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease Chang, Ya-Ting Huang, Chi-Wei Chang, Wen-Neng Lee, Jun-Jun Chang, Chiung-Chih Biomed Res Int Research Article BACKGROUND: We aimed to investigate how altered intrinsic connectivity networks (ICNs) affect pathologic changes of Alzheimer's disease (AD) at a network-based level. METHODS: Thirty normal controls (NCs), 23 patients with AD-mild cognitive impairment (MCI), and 20 patients with AD-dementia were enrolled. We compared the organization of grey matter structural covariance and functional connectivity in ICNs between NCs and all AD patients who were amyloid β (Aβ)-positive. We further used seed-based interregional covariance analysis to compare structural and Aβ plaque covariance in default mode network (DMN) between AD-MCI and AD-dementia groups. RESULTS: The patients with AD had increased functional interregional covariance among the regions of the ICN anchored to dorsal caudate (DC) seeds compared to the NCs. The increased connectivity was associated with extended patterns of reduced Aβ plaque covariance in the AD-dementia group compared to the AD-MCI group within the striatal network anchored to DC seeds. Patterns of lower Aβ plaque covariance in the AD-dementia group compared to the AD-MCI group were more extended within the network anchored to DC seeds than within the DMN, which was undergoing functional failure in the patients with AD. Significant decreased structural covariance in the AD-dementia group compared to the AD-MCI group was more extended in the DMN during functional failure. CONCLUSIONS: Functional connectivity in ICNs affects the topographic spread of molecular pathologies. The temporal trajectory of pathologic alterations can be well demonstrated by pathologic covariance comparisons between different clinical stages. Pathologic covariance can provide critical support to pathologic interactions at network and molecular levels. Hindawi 2018-12-02 /pmc/articles/PMC6304529/ /pubmed/30627575 http://dx.doi.org/10.1155/2018/8565620 Text en Copyright © 2018 Ya-Ting Chang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chang, Ya-Ting Huang, Chi-Wei Chang, Wen-Neng Lee, Jun-Jun Chang, Chiung-Chih Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease |
title | Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease |
title_full | Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease |
title_fullStr | Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease |
title_full_unstemmed | Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease |
title_short | Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease |
title_sort | altered functional network affects amyloid and structural covariance in alzheimer's disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304529/ https://www.ncbi.nlm.nih.gov/pubmed/30627575 http://dx.doi.org/10.1155/2018/8565620 |
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