Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound

The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance. The chemical structure of compound 7 (methyl 3-O-phospo-α-D-glucopyranuronic acid was elucidated by physical and advance spectral technique. Also, this compound was assessed for various i...

Descripción completa

Detalles Bibliográficos
Autores principales: Abu-Izneid, Tareq, Rauf, Abdur, Bawazeer, Saud, Wadood, Abdul, Patel, Seema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304533/
https://www.ncbi.nlm.nih.gov/pubmed/30627577
http://dx.doi.org/10.1155/2018/8648956
_version_ 1783382382085144576
author Abu-Izneid, Tareq
Rauf, Abdur
Bawazeer, Saud
Wadood, Abdul
Patel, Seema
author_facet Abu-Izneid, Tareq
Rauf, Abdur
Bawazeer, Saud
Wadood, Abdul
Patel, Seema
author_sort Abu-Izneid, Tareq
collection PubMed
description The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance. The chemical structure of compound 7 (methyl 3-O-phospo-α-D-glucopyranuronic acid was elucidated by physical and advance spectral technique. Also, this compound was assessed for various in vitro biological screening. The results showed that compound 7 has promising antifungal activity against selected fungal strains. Computational study was also carried out to find antimalarial efficacy of the synthesized compounds. Compounds (2-7) were tested for cytotoxicity by MTT assay, and no considerable cytotoxicity was observed. Molecular docking study was performed to predict the binding modes of new compound (7). The docking results revealed that the compound has strong attraction towards the target protein, as characterized by good bonding networks. On the basis of the acquired results, it can be predicted that compound (7) might show good inhibitory activity against dengue envelope protein.
format Online
Article
Text
id pubmed-6304533
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-63045332019-01-09 Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound Abu-Izneid, Tareq Rauf, Abdur Bawazeer, Saud Wadood, Abdul Patel, Seema Biomed Res Int Research Article The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance. The chemical structure of compound 7 (methyl 3-O-phospo-α-D-glucopyranuronic acid was elucidated by physical and advance spectral technique. Also, this compound was assessed for various in vitro biological screening. The results showed that compound 7 has promising antifungal activity against selected fungal strains. Computational study was also carried out to find antimalarial efficacy of the synthesized compounds. Compounds (2-7) were tested for cytotoxicity by MTT assay, and no considerable cytotoxicity was observed. Molecular docking study was performed to predict the binding modes of new compound (7). The docking results revealed that the compound has strong attraction towards the target protein, as characterized by good bonding networks. On the basis of the acquired results, it can be predicted that compound (7) might show good inhibitory activity against dengue envelope protein. Hindawi 2018-12-03 /pmc/articles/PMC6304533/ /pubmed/30627577 http://dx.doi.org/10.1155/2018/8648956 Text en Copyright © 2018 Tareq Abu-Izneid et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Abu-Izneid, Tareq
Rauf, Abdur
Bawazeer, Saud
Wadood, Abdul
Patel, Seema
Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound
title Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound
title_full Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound
title_fullStr Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound
title_full_unstemmed Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound
title_short Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound
title_sort anti-dengue, cytotoxicity, antifungal, and in silico study of the newly synthesized 3-o-phospo-α-d-glucopyranuronic acid compound
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304533/
https://www.ncbi.nlm.nih.gov/pubmed/30627577
http://dx.doi.org/10.1155/2018/8648956
work_keys_str_mv AT abuizneidtareq antidenguecytotoxicityantifungalandinsilicostudyofthenewlysynthesized3ophospoadglucopyranuronicacidcompound
AT raufabdur antidenguecytotoxicityantifungalandinsilicostudyofthenewlysynthesized3ophospoadglucopyranuronicacidcompound
AT bawazeersaud antidenguecytotoxicityantifungalandinsilicostudyofthenewlysynthesized3ophospoadglucopyranuronicacidcompound
AT wadoodabdul antidenguecytotoxicityantifungalandinsilicostudyofthenewlysynthesized3ophospoadglucopyranuronicacidcompound
AT patelseema antidenguecytotoxicityantifungalandinsilicostudyofthenewlysynthesized3ophospoadglucopyranuronicacidcompound

Ejemplares similares