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The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study

BACKGROUND: The prevalence of hypertension in children increases rapidly. This paper is to investigate the association of vitamin A and serum 25(OH)D level with hypertension and to explore the risk factors of hypertension in children. METHODS: 164 children (age: 6-12 years, females: 49.39%) were inc...

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Autores principales: Liang, Xiaohua, Chen, Min, Qu, Ping, Hao, Guang, Huang, Yisong, Chen, Jie, Li, Tingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304547/
https://www.ncbi.nlm.nih.gov/pubmed/30631592
http://dx.doi.org/10.1155/2018/9295147
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author Liang, Xiaohua
Chen, Min
Qu, Ping
Hao, Guang
Huang, Yisong
Chen, Jie
Li, Tingyu
author_facet Liang, Xiaohua
Chen, Min
Qu, Ping
Hao, Guang
Huang, Yisong
Chen, Jie
Li, Tingyu
author_sort Liang, Xiaohua
collection PubMed
description BACKGROUND: The prevalence of hypertension in children increases rapidly. This paper is to investigate the association of vitamin A and serum 25(OH)D level with hypertension and to explore the risk factors of hypertension in children. METHODS: 164 children (age: 6-12 years, females: 49.39%) were included in this case-control study. The serum vitamin A and serum 25(OH)D level, the transcription level of RARs and RXRs, 25(OH)D receptor, and the retinol acyltransferase (LRAT), an indicator of vitamin A storage function, were measured. RESULTS: The serum vitamin A level in hypertensive subjects was not significantly different compared to control, but the serum 25(OH)D level was significantly lower in hypertensive subjects compared to control (38.22±12.00umol/L vs. 43.28±12.33 umol/L, P=0.02). The transcription levels of RARα, RARβ, and RARγ were not significantly different between the two groups; but the LRAT was lower in the hypertensive group than that in the control (P<0.001). Compared with control group, the level of 25(OH)D receptor was lower in hypertension children (P=0.003). Logistic regression model showed that LRAT, HDL, and breastfed duration were negatively associated with blood pressure, and waist circumference was positively associated with blood pressure. CONCLUSIONS: The LRAT, serum 25(OH)D, and 25(OH)D receptor were significantly associated with blood pressure level, and both breastfed and HDL-C were independent protective factors of blood pressure level in children.
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spelling pubmed-63045472019-01-10 The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study Liang, Xiaohua Chen, Min Qu, Ping Hao, Guang Huang, Yisong Chen, Jie Li, Tingyu Int J Hypertens Research Article BACKGROUND: The prevalence of hypertension in children increases rapidly. This paper is to investigate the association of vitamin A and serum 25(OH)D level with hypertension and to explore the risk factors of hypertension in children. METHODS: 164 children (age: 6-12 years, females: 49.39%) were included in this case-control study. The serum vitamin A and serum 25(OH)D level, the transcription level of RARs and RXRs, 25(OH)D receptor, and the retinol acyltransferase (LRAT), an indicator of vitamin A storage function, were measured. RESULTS: The serum vitamin A level in hypertensive subjects was not significantly different compared to control, but the serum 25(OH)D level was significantly lower in hypertensive subjects compared to control (38.22±12.00umol/L vs. 43.28±12.33 umol/L, P=0.02). The transcription levels of RARα, RARβ, and RARγ were not significantly different between the two groups; but the LRAT was lower in the hypertensive group than that in the control (P<0.001). Compared with control group, the level of 25(OH)D receptor was lower in hypertension children (P=0.003). Logistic regression model showed that LRAT, HDL, and breastfed duration were negatively associated with blood pressure, and waist circumference was positively associated with blood pressure. CONCLUSIONS: The LRAT, serum 25(OH)D, and 25(OH)D receptor were significantly associated with blood pressure level, and both breastfed and HDL-C were independent protective factors of blood pressure level in children. Hindawi 2018-12-06 /pmc/articles/PMC6304547/ /pubmed/30631592 http://dx.doi.org/10.1155/2018/9295147 Text en Copyright © 2018 Xiaohua Liang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liang, Xiaohua
Chen, Min
Qu, Ping
Hao, Guang
Huang, Yisong
Chen, Jie
Li, Tingyu
The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
title The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
title_full The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
title_fullStr The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
title_full_unstemmed The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
title_short The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
title_sort association of vitamin a and vitamin d with hypertension in children: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304547/
https://www.ncbi.nlm.nih.gov/pubmed/30631592
http://dx.doi.org/10.1155/2018/9295147
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