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The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study
BACKGROUND: The prevalence of hypertension in children increases rapidly. This paper is to investigate the association of vitamin A and serum 25(OH)D level with hypertension and to explore the risk factors of hypertension in children. METHODS: 164 children (age: 6-12 years, females: 49.39%) were inc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304547/ https://www.ncbi.nlm.nih.gov/pubmed/30631592 http://dx.doi.org/10.1155/2018/9295147 |
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author | Liang, Xiaohua Chen, Min Qu, Ping Hao, Guang Huang, Yisong Chen, Jie Li, Tingyu |
author_facet | Liang, Xiaohua Chen, Min Qu, Ping Hao, Guang Huang, Yisong Chen, Jie Li, Tingyu |
author_sort | Liang, Xiaohua |
collection | PubMed |
description | BACKGROUND: The prevalence of hypertension in children increases rapidly. This paper is to investigate the association of vitamin A and serum 25(OH)D level with hypertension and to explore the risk factors of hypertension in children. METHODS: 164 children (age: 6-12 years, females: 49.39%) were included in this case-control study. The serum vitamin A and serum 25(OH)D level, the transcription level of RARs and RXRs, 25(OH)D receptor, and the retinol acyltransferase (LRAT), an indicator of vitamin A storage function, were measured. RESULTS: The serum vitamin A level in hypertensive subjects was not significantly different compared to control, but the serum 25(OH)D level was significantly lower in hypertensive subjects compared to control (38.22±12.00umol/L vs. 43.28±12.33 umol/L, P=0.02). The transcription levels of RARα, RARβ, and RARγ were not significantly different between the two groups; but the LRAT was lower in the hypertensive group than that in the control (P<0.001). Compared with control group, the level of 25(OH)D receptor was lower in hypertension children (P=0.003). Logistic regression model showed that LRAT, HDL, and breastfed duration were negatively associated with blood pressure, and waist circumference was positively associated with blood pressure. CONCLUSIONS: The LRAT, serum 25(OH)D, and 25(OH)D receptor were significantly associated with blood pressure level, and both breastfed and HDL-C were independent protective factors of blood pressure level in children. |
format | Online Article Text |
id | pubmed-6304547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63045472019-01-10 The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study Liang, Xiaohua Chen, Min Qu, Ping Hao, Guang Huang, Yisong Chen, Jie Li, Tingyu Int J Hypertens Research Article BACKGROUND: The prevalence of hypertension in children increases rapidly. This paper is to investigate the association of vitamin A and serum 25(OH)D level with hypertension and to explore the risk factors of hypertension in children. METHODS: 164 children (age: 6-12 years, females: 49.39%) were included in this case-control study. The serum vitamin A and serum 25(OH)D level, the transcription level of RARs and RXRs, 25(OH)D receptor, and the retinol acyltransferase (LRAT), an indicator of vitamin A storage function, were measured. RESULTS: The serum vitamin A level in hypertensive subjects was not significantly different compared to control, but the serum 25(OH)D level was significantly lower in hypertensive subjects compared to control (38.22±12.00umol/L vs. 43.28±12.33 umol/L, P=0.02). The transcription levels of RARα, RARβ, and RARγ were not significantly different between the two groups; but the LRAT was lower in the hypertensive group than that in the control (P<0.001). Compared with control group, the level of 25(OH)D receptor was lower in hypertension children (P=0.003). Logistic regression model showed that LRAT, HDL, and breastfed duration were negatively associated with blood pressure, and waist circumference was positively associated with blood pressure. CONCLUSIONS: The LRAT, serum 25(OH)D, and 25(OH)D receptor were significantly associated with blood pressure level, and both breastfed and HDL-C were independent protective factors of blood pressure level in children. Hindawi 2018-12-06 /pmc/articles/PMC6304547/ /pubmed/30631592 http://dx.doi.org/10.1155/2018/9295147 Text en Copyright © 2018 Xiaohua Liang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liang, Xiaohua Chen, Min Qu, Ping Hao, Guang Huang, Yisong Chen, Jie Li, Tingyu The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study |
title | The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study |
title_full | The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study |
title_fullStr | The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study |
title_full_unstemmed | The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study |
title_short | The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study |
title_sort | association of vitamin a and vitamin d with hypertension in children: a case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304547/ https://www.ncbi.nlm.nih.gov/pubmed/30631592 http://dx.doi.org/10.1155/2018/9295147 |
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