Cargando…

Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen, and mutagen. In our previous study, a candidate gallic acid (GA) that widely exists in food and fruit was selected for its capability to alleviate DMN toxicity in vivo. We aimed to investigate the therapeutic potential of GA against DMN-...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yuxin, Zhou, Ziping, Mo, Qigui, Zhou, Gao, Wang, Youwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304566/
https://www.ncbi.nlm.nih.gov/pubmed/30627538
http://dx.doi.org/10.1155/2018/1682743
_version_ 1783382389922201600
author Chen, Yuxin
Zhou, Ziping
Mo, Qigui
Zhou, Gao
Wang, Youwei
author_facet Chen, Yuxin
Zhou, Ziping
Mo, Qigui
Zhou, Gao
Wang, Youwei
author_sort Chen, Yuxin
collection PubMed
description Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen, and mutagen. In our previous study, a candidate gallic acid (GA) that widely exists in food and fruit was selected for its capability to alleviate DMN toxicity in vivo. We aimed to investigate the therapeutic potential of GA against DMN-induced liver fibrosis. During the first four weeks, DMN was administered to rats via intraperitoneal injection every other day, except the control group. GA or silymarin was given to rats by gavage once daily from the second to the sixth week. GA significantly reduced liver damage in serum parameters and improved the antioxidant capacity in liver and kidney tissues. Cytokines involved in liver fibrosis were measured at transcriptional and translational levels. These results indicate that GA exhibits robust antioxidant and antifibrosis effects and may be an effective candidate natural medicine for liver fibrosis treatment.
format Online
Article
Text
id pubmed-6304566
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-63045662019-01-09 Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats Chen, Yuxin Zhou, Ziping Mo, Qigui Zhou, Gao Wang, Youwei Biomed Res Int Research Article Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen, and mutagen. In our previous study, a candidate gallic acid (GA) that widely exists in food and fruit was selected for its capability to alleviate DMN toxicity in vivo. We aimed to investigate the therapeutic potential of GA against DMN-induced liver fibrosis. During the first four weeks, DMN was administered to rats via intraperitoneal injection every other day, except the control group. GA or silymarin was given to rats by gavage once daily from the second to the sixth week. GA significantly reduced liver damage in serum parameters and improved the antioxidant capacity in liver and kidney tissues. Cytokines involved in liver fibrosis were measured at transcriptional and translational levels. These results indicate that GA exhibits robust antioxidant and antifibrosis effects and may be an effective candidate natural medicine for liver fibrosis treatment. Hindawi 2018-12-02 /pmc/articles/PMC6304566/ /pubmed/30627538 http://dx.doi.org/10.1155/2018/1682743 Text en Copyright © 2018 Yuxin Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Yuxin
Zhou, Ziping
Mo, Qigui
Zhou, Gao
Wang, Youwei
Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
title Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
title_full Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
title_fullStr Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
title_full_unstemmed Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
title_short Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
title_sort gallic acid attenuates dimethylnitrosamine-induced liver fibrosis by alteration of smad phosphoisoform signaling in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304566/
https://www.ncbi.nlm.nih.gov/pubmed/30627538
http://dx.doi.org/10.1155/2018/1682743
work_keys_str_mv AT chenyuxin gallicacidattenuatesdimethylnitrosamineinducedliverfibrosisbyalterationofsmadphosphoisoformsignalinginrats
AT zhouziping gallicacidattenuatesdimethylnitrosamineinducedliverfibrosisbyalterationofsmadphosphoisoformsignalinginrats
AT moqigui gallicacidattenuatesdimethylnitrosamineinducedliverfibrosisbyalterationofsmadphosphoisoformsignalinginrats
AT zhougao gallicacidattenuatesdimethylnitrosamineinducedliverfibrosisbyalterationofsmadphosphoisoformsignalinginrats
AT wangyouwei gallicacidattenuatesdimethylnitrosamineinducedliverfibrosisbyalterationofsmadphosphoisoformsignalinginrats