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Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development

Entamoeba histolytica is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in nonendemic areas. Although the majority of individuals infected...

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Autores principales: Kantor, Micaella, Abrantes, Anarella, Estevez, Andrea, Schiller, Alan, Torrent, Jose, Gascon, Jose, Hernandez, Robert, Ochner, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304615/
https://www.ncbi.nlm.nih.gov/pubmed/30631758
http://dx.doi.org/10.1155/2018/4601420
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author Kantor, Micaella
Abrantes, Anarella
Estevez, Andrea
Schiller, Alan
Torrent, Jose
Gascon, Jose
Hernandez, Robert
Ochner, Christopher
author_facet Kantor, Micaella
Abrantes, Anarella
Estevez, Andrea
Schiller, Alan
Torrent, Jose
Gascon, Jose
Hernandez, Robert
Ochner, Christopher
author_sort Kantor, Micaella
collection PubMed
description Entamoeba histolytica is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in nonendemic areas. Although the majority of individuals infected with E. histolytica remain asymptomatic, some present with amoebic colitis and disseminated disease. As more is learned about its pathogenesis and the host's immune response, the potential for developing a vaccine holds promise. This narrative review outlines the current knowledge regarding E. histolytica and E. dispar and insight in the development of a vaccine.
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spelling pubmed-63046152019-01-10 Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development Kantor, Micaella Abrantes, Anarella Estevez, Andrea Schiller, Alan Torrent, Jose Gascon, Jose Hernandez, Robert Ochner, Christopher Can J Gastroenterol Hepatol Review Article Entamoeba histolytica is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in nonendemic areas. Although the majority of individuals infected with E. histolytica remain asymptomatic, some present with amoebic colitis and disseminated disease. As more is learned about its pathogenesis and the host's immune response, the potential for developing a vaccine holds promise. This narrative review outlines the current knowledge regarding E. histolytica and E. dispar and insight in the development of a vaccine. Hindawi 2018-12-02 /pmc/articles/PMC6304615/ /pubmed/30631758 http://dx.doi.org/10.1155/2018/4601420 Text en Copyright © 2018 Micaella Kantor et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kantor, Micaella
Abrantes, Anarella
Estevez, Andrea
Schiller, Alan
Torrent, Jose
Gascon, Jose
Hernandez, Robert
Ochner, Christopher
Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development
title Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development
title_full Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development
title_fullStr Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development
title_full_unstemmed Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development
title_short Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development
title_sort entamoeba histolytica: updates in clinical manifestation, pathogenesis, and vaccine development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304615/
https://www.ncbi.nlm.nih.gov/pubmed/30631758
http://dx.doi.org/10.1155/2018/4601420
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