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Do MicroRNAs Modulate Visceral Pain?
Visceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304628/ https://www.ncbi.nlm.nih.gov/pubmed/30627562 http://dx.doi.org/10.1155/2018/5406973 |
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author | Tao, Zhuo-Ying Xue, Yang Li, Jin-Feng Traub, Richard J. Cao, Dong-Yuan |
author_facet | Tao, Zhuo-Ying Xue, Yang Li, Jin-Feng Traub, Richard J. Cao, Dong-Yuan |
author_sort | Tao, Zhuo-Ying |
collection | PubMed |
description | Visceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (miRNAs) play a significant role in visceral nociception through altering neurotransmitters, receptors and other genes at the posttranscriptional level. Under pathological conditions, one kind of miRNA may have several target mRNAs and several kinds of miRNAs may act on one target, suggesting complex interactions and mechanisms between miRNAs and target genes lead to pathological states. In this review we report on recent progress in examining miRNAs responsible for visceral sensitization and provide miRNA-based therapeutic targets for the management of visceral pain. |
format | Online Article Text |
id | pubmed-6304628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63046282019-01-09 Do MicroRNAs Modulate Visceral Pain? Tao, Zhuo-Ying Xue, Yang Li, Jin-Feng Traub, Richard J. Cao, Dong-Yuan Biomed Res Int Review Article Visceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (miRNAs) play a significant role in visceral nociception through altering neurotransmitters, receptors and other genes at the posttranscriptional level. Under pathological conditions, one kind of miRNA may have several target mRNAs and several kinds of miRNAs may act on one target, suggesting complex interactions and mechanisms between miRNAs and target genes lead to pathological states. In this review we report on recent progress in examining miRNAs responsible for visceral sensitization and provide miRNA-based therapeutic targets for the management of visceral pain. Hindawi 2018-10-10 /pmc/articles/PMC6304628/ /pubmed/30627562 http://dx.doi.org/10.1155/2018/5406973 Text en Copyright © 2018 Zhuo-Ying Tao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tao, Zhuo-Ying Xue, Yang Li, Jin-Feng Traub, Richard J. Cao, Dong-Yuan Do MicroRNAs Modulate Visceral Pain? |
title | Do MicroRNAs Modulate Visceral Pain? |
title_full | Do MicroRNAs Modulate Visceral Pain? |
title_fullStr | Do MicroRNAs Modulate Visceral Pain? |
title_full_unstemmed | Do MicroRNAs Modulate Visceral Pain? |
title_short | Do MicroRNAs Modulate Visceral Pain? |
title_sort | do micrornas modulate visceral pain? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304628/ https://www.ncbi.nlm.nih.gov/pubmed/30627562 http://dx.doi.org/10.1155/2018/5406973 |
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