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Do MicroRNAs Modulate Visceral Pain?

Visceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (...

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Detalles Bibliográficos
Autores principales: Tao, Zhuo-Ying, Xue, Yang, Li, Jin-Feng, Traub, Richard J., Cao, Dong-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304628/
https://www.ncbi.nlm.nih.gov/pubmed/30627562
http://dx.doi.org/10.1155/2018/5406973
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author Tao, Zhuo-Ying
Xue, Yang
Li, Jin-Feng
Traub, Richard J.
Cao, Dong-Yuan
author_facet Tao, Zhuo-Ying
Xue, Yang
Li, Jin-Feng
Traub, Richard J.
Cao, Dong-Yuan
author_sort Tao, Zhuo-Ying
collection PubMed
description Visceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (miRNAs) play a significant role in visceral nociception through altering neurotransmitters, receptors and other genes at the posttranscriptional level. Under pathological conditions, one kind of miRNA may have several target mRNAs and several kinds of miRNAs may act on one target, suggesting complex interactions and mechanisms between miRNAs and target genes lead to pathological states. In this review we report on recent progress in examining miRNAs responsible for visceral sensitization and provide miRNA-based therapeutic targets for the management of visceral pain.
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spelling pubmed-63046282019-01-09 Do MicroRNAs Modulate Visceral Pain? Tao, Zhuo-Ying Xue, Yang Li, Jin-Feng Traub, Richard J. Cao, Dong-Yuan Biomed Res Int Review Article Visceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (miRNAs) play a significant role in visceral nociception through altering neurotransmitters, receptors and other genes at the posttranscriptional level. Under pathological conditions, one kind of miRNA may have several target mRNAs and several kinds of miRNAs may act on one target, suggesting complex interactions and mechanisms between miRNAs and target genes lead to pathological states. In this review we report on recent progress in examining miRNAs responsible for visceral sensitization and provide miRNA-based therapeutic targets for the management of visceral pain. Hindawi 2018-10-10 /pmc/articles/PMC6304628/ /pubmed/30627562 http://dx.doi.org/10.1155/2018/5406973 Text en Copyright © 2018 Zhuo-Ying Tao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tao, Zhuo-Ying
Xue, Yang
Li, Jin-Feng
Traub, Richard J.
Cao, Dong-Yuan
Do MicroRNAs Modulate Visceral Pain?
title Do MicroRNAs Modulate Visceral Pain?
title_full Do MicroRNAs Modulate Visceral Pain?
title_fullStr Do MicroRNAs Modulate Visceral Pain?
title_full_unstemmed Do MicroRNAs Modulate Visceral Pain?
title_short Do MicroRNAs Modulate Visceral Pain?
title_sort do micrornas modulate visceral pain?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304628/
https://www.ncbi.nlm.nih.gov/pubmed/30627562
http://dx.doi.org/10.1155/2018/5406973
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