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Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074
SNCA-rs11931074 had been demonstrated to be strongly correlated with PD risk. However, there was lack of comprehensive analysis of SNCA-rs11931074-related clinical features which may help explain clinical heterogeneity of PD. In our study, we performed association analyses on the relationship betwee...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304873/ https://www.ncbi.nlm.nih.gov/pubmed/30631417 http://dx.doi.org/10.1155/2018/2754541 |
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author | Shu, Li Liang, Dongxiao Pan, Hongxu Xu, Qian Guo, Jifeng Sun, Qiying Tang, Beisha Yan, Xinxiang |
author_facet | Shu, Li Liang, Dongxiao Pan, Hongxu Xu, Qian Guo, Jifeng Sun, Qiying Tang, Beisha Yan, Xinxiang |
author_sort | Shu, Li |
collection | PubMed |
description | SNCA-rs11931074 had been demonstrated to be strongly correlated with PD risk. However, there was lack of comprehensive analysis of SNCA-rs11931074-related clinical features which may help explain clinical heterogeneity of PD. In our study, we performed association analyses on the relationship between SNCA-rs11931074 and motor symptoms, nonmotor symptoms, and comorbidities in PD. 611 rs11931074 carriers and 113 rs11931074 noncarriers were enrolled. In the clinical phenotype analyses, the Unified Parkinson's Disease Rating Scale part II (UPDRS II) and part III (UPDRS III) scores of rs11931074 carriers were lower than those of noncarriers (SC: −0.083, p=0.035; SC: −0.140, p ≤ 0.001). The Charlson Comorbidity Index (CCI) score of carriers was lower than that of noncarriers (SC: −0.097, p=0.009). No significant statistical differences were found between the variant and other clinical features such as motor complications and nonmotor symptoms. The SNCA-rs11931074 carriers may present with more benign clinical profiles than noncarriers with less severe motor symptoms and comorbidity burden. |
format | Online Article Text |
id | pubmed-6304873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63048732019-01-10 Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074 Shu, Li Liang, Dongxiao Pan, Hongxu Xu, Qian Guo, Jifeng Sun, Qiying Tang, Beisha Yan, Xinxiang Parkinsons Dis Research Article SNCA-rs11931074 had been demonstrated to be strongly correlated with PD risk. However, there was lack of comprehensive analysis of SNCA-rs11931074-related clinical features which may help explain clinical heterogeneity of PD. In our study, we performed association analyses on the relationship between SNCA-rs11931074 and motor symptoms, nonmotor symptoms, and comorbidities in PD. 611 rs11931074 carriers and 113 rs11931074 noncarriers were enrolled. In the clinical phenotype analyses, the Unified Parkinson's Disease Rating Scale part II (UPDRS II) and part III (UPDRS III) scores of rs11931074 carriers were lower than those of noncarriers (SC: −0.083, p=0.035; SC: −0.140, p ≤ 0.001). The Charlson Comorbidity Index (CCI) score of carriers was lower than that of noncarriers (SC: −0.097, p=0.009). No significant statistical differences were found between the variant and other clinical features such as motor complications and nonmotor symptoms. The SNCA-rs11931074 carriers may present with more benign clinical profiles than noncarriers with less severe motor symptoms and comorbidity burden. Hindawi 2018-12-03 /pmc/articles/PMC6304873/ /pubmed/30631417 http://dx.doi.org/10.1155/2018/2754541 Text en Copyright © 2018 Li Shu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shu, Li Liang, Dongxiao Pan, Hongxu Xu, Qian Guo, Jifeng Sun, Qiying Tang, Beisha Yan, Xinxiang Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074 |
title | Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074 |
title_full | Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074 |
title_fullStr | Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074 |
title_full_unstemmed | Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074 |
title_short | Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074 |
title_sort | genetic impact on clinical features in parkinson's disease: a study on snca-rs11931074 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304873/ https://www.ncbi.nlm.nih.gov/pubmed/30631417 http://dx.doi.org/10.1155/2018/2754541 |
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