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Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074

SNCA-rs11931074 had been demonstrated to be strongly correlated with PD risk. However, there was lack of comprehensive analysis of SNCA-rs11931074-related clinical features which may help explain clinical heterogeneity of PD. In our study, we performed association analyses on the relationship betwee...

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Autores principales: Shu, Li, Liang, Dongxiao, Pan, Hongxu, Xu, Qian, Guo, Jifeng, Sun, Qiying, Tang, Beisha, Yan, Xinxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304873/
https://www.ncbi.nlm.nih.gov/pubmed/30631417
http://dx.doi.org/10.1155/2018/2754541
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author Shu, Li
Liang, Dongxiao
Pan, Hongxu
Xu, Qian
Guo, Jifeng
Sun, Qiying
Tang, Beisha
Yan, Xinxiang
author_facet Shu, Li
Liang, Dongxiao
Pan, Hongxu
Xu, Qian
Guo, Jifeng
Sun, Qiying
Tang, Beisha
Yan, Xinxiang
author_sort Shu, Li
collection PubMed
description SNCA-rs11931074 had been demonstrated to be strongly correlated with PD risk. However, there was lack of comprehensive analysis of SNCA-rs11931074-related clinical features which may help explain clinical heterogeneity of PD. In our study, we performed association analyses on the relationship between SNCA-rs11931074 and motor symptoms, nonmotor symptoms, and comorbidities in PD. 611 rs11931074 carriers and 113 rs11931074 noncarriers were enrolled. In the clinical phenotype analyses, the Unified Parkinson's Disease Rating Scale part II (UPDRS II) and part III (UPDRS III) scores of rs11931074 carriers were lower than those of noncarriers (SC: −0.083, p=0.035; SC: −0.140, p ≤ 0.001). The Charlson Comorbidity Index (CCI) score of carriers was lower than that of noncarriers (SC: −0.097, p=0.009). No significant statistical differences were found between the variant and other clinical features such as motor complications and nonmotor symptoms. The SNCA-rs11931074 carriers may present with more benign clinical profiles than noncarriers with less severe motor symptoms and comorbidity burden.
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spelling pubmed-63048732019-01-10 Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074 Shu, Li Liang, Dongxiao Pan, Hongxu Xu, Qian Guo, Jifeng Sun, Qiying Tang, Beisha Yan, Xinxiang Parkinsons Dis Research Article SNCA-rs11931074 had been demonstrated to be strongly correlated with PD risk. However, there was lack of comprehensive analysis of SNCA-rs11931074-related clinical features which may help explain clinical heterogeneity of PD. In our study, we performed association analyses on the relationship between SNCA-rs11931074 and motor symptoms, nonmotor symptoms, and comorbidities in PD. 611 rs11931074 carriers and 113 rs11931074 noncarriers were enrolled. In the clinical phenotype analyses, the Unified Parkinson's Disease Rating Scale part II (UPDRS II) and part III (UPDRS III) scores of rs11931074 carriers were lower than those of noncarriers (SC: −0.083, p=0.035; SC: −0.140, p ≤ 0.001). The Charlson Comorbidity Index (CCI) score of carriers was lower than that of noncarriers (SC: −0.097, p=0.009). No significant statistical differences were found between the variant and other clinical features such as motor complications and nonmotor symptoms. The SNCA-rs11931074 carriers may present with more benign clinical profiles than noncarriers with less severe motor symptoms and comorbidity burden. Hindawi 2018-12-03 /pmc/articles/PMC6304873/ /pubmed/30631417 http://dx.doi.org/10.1155/2018/2754541 Text en Copyright © 2018 Li Shu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shu, Li
Liang, Dongxiao
Pan, Hongxu
Xu, Qian
Guo, Jifeng
Sun, Qiying
Tang, Beisha
Yan, Xinxiang
Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074
title Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074
title_full Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074
title_fullStr Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074
title_full_unstemmed Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074
title_short Genetic Impact on Clinical Features in Parkinson's Disease: A Study on SNCA-rs11931074
title_sort genetic impact on clinical features in parkinson's disease: a study on snca-rs11931074
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304873/
https://www.ncbi.nlm.nih.gov/pubmed/30631417
http://dx.doi.org/10.1155/2018/2754541
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