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Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy
Autophagy is a protein and organelle degradation pathway important for the maintenance of cytoplasmic homeostasis and for providing nutrients for survival in response to stress conditions. Recently, autophagy has been shown to be important for the secretion of diverse proteins involved in inflammati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304875/ https://www.ncbi.nlm.nih.gov/pubmed/30622432 http://dx.doi.org/10.1155/2018/4231591 |
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author | Cotzomi-Ortega, Israel Aguilar-Alonso, Patricia Reyes-Leyva, Julio Maycotte, Paola |
author_facet | Cotzomi-Ortega, Israel Aguilar-Alonso, Patricia Reyes-Leyva, Julio Maycotte, Paola |
author_sort | Cotzomi-Ortega, Israel |
collection | PubMed |
description | Autophagy is a protein and organelle degradation pathway important for the maintenance of cytoplasmic homeostasis and for providing nutrients for survival in response to stress conditions. Recently, autophagy has been shown to be important for the secretion of diverse proteins involved in inflammation, intercellular signaling, and cancer progression. The role of autophagy in cancer depends on the stage of tumorigenesis, serving a tumor-suppressor role before transformation and a tumor-survival function once a tumor is established. We review recent evidence demonstrating the complexity of autophagy regulation during cancer, considering the interaction of autophagy with protein secretion pathways. Autophagy manipulation during cancer treatment is likely to affect protein secretion andinter-cellular signaling either to the neighboring cancer cells or to the antitumoral immune response. This will be an important consideration during cancer therapy since several clinical trials are trying to manipulate autophagy in combination with chemotherapy for the treatment of diverse types of cancers. |
format | Online Article Text |
id | pubmed-6304875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63048752019-01-08 Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy Cotzomi-Ortega, Israel Aguilar-Alonso, Patricia Reyes-Leyva, Julio Maycotte, Paola Mediators Inflamm Review Article Autophagy is a protein and organelle degradation pathway important for the maintenance of cytoplasmic homeostasis and for providing nutrients for survival in response to stress conditions. Recently, autophagy has been shown to be important for the secretion of diverse proteins involved in inflammation, intercellular signaling, and cancer progression. The role of autophagy in cancer depends on the stage of tumorigenesis, serving a tumor-suppressor role before transformation and a tumor-survival function once a tumor is established. We review recent evidence demonstrating the complexity of autophagy regulation during cancer, considering the interaction of autophagy with protein secretion pathways. Autophagy manipulation during cancer treatment is likely to affect protein secretion andinter-cellular signaling either to the neighboring cancer cells or to the antitumoral immune response. This will be an important consideration during cancer therapy since several clinical trials are trying to manipulate autophagy in combination with chemotherapy for the treatment of diverse types of cancers. Hindawi 2018-12-06 /pmc/articles/PMC6304875/ /pubmed/30622432 http://dx.doi.org/10.1155/2018/4231591 Text en Copyright © 2018 Israel Cotzomi-Ortega et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cotzomi-Ortega, Israel Aguilar-Alonso, Patricia Reyes-Leyva, Julio Maycotte, Paola Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy |
title | Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy |
title_full | Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy |
title_fullStr | Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy |
title_full_unstemmed | Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy |
title_short | Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy |
title_sort | autophagy and its role in protein secretion: implications for cancer therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304875/ https://www.ncbi.nlm.nih.gov/pubmed/30622432 http://dx.doi.org/10.1155/2018/4231591 |
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