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Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate
Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and regenerative medicine due to their self-renewal and differentiation capacities. The majority of current PSC protocols rely on 2D cultures and soluble factors to guide differentiation; however, many other envir...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304878/ https://www.ncbi.nlm.nih.gov/pubmed/30627175 http://dx.doi.org/10.1155/2018/9068203 |
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author | Bertucci, Taylor B. Dai, Guohao |
author_facet | Bertucci, Taylor B. Dai, Guohao |
author_sort | Bertucci, Taylor B. |
collection | PubMed |
description | Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and regenerative medicine due to their self-renewal and differentiation capacities. The majority of current PSC protocols rely on 2D cultures and soluble factors to guide differentiation; however, many other environmental signals are beginning to be explored using biomaterial platforms. Biomaterials offer new opportunities to engineer the stem cell niches and 3D environments for exploring biophysical and immobilized signaling cues to further our control over stem cell fate. Here, we review the biomaterial platforms that have been engineered to control PSC fate. We explore how altering immobilized biochemical cues and biophysical cues such as dimensionality, stiffness, and topography can enhance our control over stem cell fates. Finally, we highlight biomaterial culture systems that assist in the translation of PSC technologies for clinical applications. |
format | Online Article Text |
id | pubmed-6304878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63048782019-01-09 Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate Bertucci, Taylor B. Dai, Guohao Stem Cells Int Review Article Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and regenerative medicine due to their self-renewal and differentiation capacities. The majority of current PSC protocols rely on 2D cultures and soluble factors to guide differentiation; however, many other environmental signals are beginning to be explored using biomaterial platforms. Biomaterials offer new opportunities to engineer the stem cell niches and 3D environments for exploring biophysical and immobilized signaling cues to further our control over stem cell fate. Here, we review the biomaterial platforms that have been engineered to control PSC fate. We explore how altering immobilized biochemical cues and biophysical cues such as dimensionality, stiffness, and topography can enhance our control over stem cell fates. Finally, we highlight biomaterial culture systems that assist in the translation of PSC technologies for clinical applications. Hindawi 2018-12-05 /pmc/articles/PMC6304878/ /pubmed/30627175 http://dx.doi.org/10.1155/2018/9068203 Text en Copyright © 2018 Taylor B. Bertucci and Guohao Dai. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bertucci, Taylor B. Dai, Guohao Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate |
title | Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate |
title_full | Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate |
title_fullStr | Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate |
title_full_unstemmed | Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate |
title_short | Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate |
title_sort | biomaterial engineering for controlling pluripotent stem cell fate |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304878/ https://www.ncbi.nlm.nih.gov/pubmed/30627175 http://dx.doi.org/10.1155/2018/9068203 |
work_keys_str_mv | AT bertuccitaylorb biomaterialengineeringforcontrollingpluripotentstemcellfate AT daiguohao biomaterialengineeringforcontrollingpluripotentstemcellfate |