Cargando…

Palmitate Stimulates the Epithelial Sodium Channel by Elevating Intracellular Calcium, Reactive Oxygen Species, and Phosphoinositide 3-Kinase Activity

Previous studies indicate that the epithelial sodium channel (ENaC) in the kidney is upregulated in diabetes mellitus. Here, we show that ENaC single-channel activity in distal nephron cells was significantly increased by palmitate, a free fatty acid which is elevated in diabetes mellitus. We also s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qiu-Shi, Liang, Chen, Niu, Na, Yang, Xu, Chen, Xiao, Song, Bin-Lin, Yu, Chang-Jiang, Wu, Ming-Ming, Zhang, Zhi-Ren, Ma, He-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304918/ https://www.ncbi.nlm.nih.gov/pubmed/30622672 http://dx.doi.org/10.1155/2018/7560610

Ejemplares similares

Phosphoinositides and intracellular calcium signaling: novel insights into phosphoinositides and calcium coupling as negative regulators of cellular signaling
por: Oh, Byung-Chul
Publicado: (2023)

Phosphoinositide regulation of voltage-gated sodium channels
por: Short, Ben
Publicado: (2023)

Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer
por: Akhiani, Ali A., et al.
Publicado: (2022)

Glibenclamide Decreases ATP-Induced Intracellular Calcium Transient Elevation via Inhibiting Reactive Oxygen Species and Mitochondrial Activity in Macrophages
por: Li, Duo-ling, et al.
Publicado: (2014)

Intracellular Redistribution of Sodium and Calcium During Stimulation of Sodium Transport in Epithelial Cells
por: Zadunaisky, José A., et al.
Publicado: (1968)

Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC
por: Garcia-Caballero, Agustin, et al.
Publicado: (2019)

Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels
por: Klug, Nicholas R., et al.
Publicado: (2023)

Induction of Filopodia by Direct Local Elevation of Intracellular Calcium Ion Concentration
por: Lau, Pak-ming, et al.
Publicado: (1999)

Sodium-Glucose Cotransporter-2 Inhibitors for Hyperglycemia in Phosphoinositide 3-kinase Pathway Inhibition
por: Weintraub, Michael A, et al.
Publicado: (2023)

Intracellular sodium elevation reprograms cardiac metabolism
por: Aksentijević, Dunja, et al.
Publicado: (2020)

Role of Calcium/Calcineurin Signalling in Regulating Intracellular Reactive Oxygen Species Homeostasis in Saccharomyces cerevisiae
por: Li, Guohui, et al.
Publicado: (2021)

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)
por: Huang, Xueqin, et al.
Publicado: (2023)

Involvement of calcium channels and intracellular calcium in bull sperm thermotaxis
por: MONDAL, Md Anisuzzaman, et al.
Publicado: (2016)

Morroniside Promotes PGC-1α-Mediated Cholesterol Efflux in Sodium Palmitate or High Glucose-Induced Mouse Renal Tubular Epithelial Cells
por: Gao, Junwei, et al.
Publicado: (2021)

Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity
por: Morabito, C., et al.
Publicado: (2017)

The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction
por: Picas, Laura, et al.
Publicado: (2016)

Sodium-Calcium Exchange in Intracellular Calcium Handling of Human Airway Smooth Muscle
por: Sathish, Venkatachalem, et al.
Publicado: (2011)

Regulation of the sodium permeability of the luminal border of toad bladder by intracellular sodium and calcium: role of sodium-calcium exchange in the basolateral membrane
Publicado: (1981)

Transient receptor potential channels meet phosphoinositides
por: Nilius, Bernd, et al.
Publicado: (2008)

Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels
por: Wang, Ya-Jean, et al.
Publicado: (2016)

Phosphoinositide-3-Kinase Is the Primary Mediator of Phosphoinositide-Dependent Inhibition in Mammalian Olfactory Receptor Neurons
por: Ukhanov, Kirill, et al.
Publicado: (2016)

Phosphoinositide 3-Kinase Inhibitor-Induced Hyperglycemia
por: Shey, Susan, et al.
Publicado: (2021)

Photocatalytic Activity of Polymer Nanoparticles Modulates Intracellular Calcium Dynamics and Reactive Oxygen Species in HEK-293 Cells
por: Bossio, Caterina, et al.
Publicado: (2018)

Prostasin: An Epithelial Sodium Channel Regulator
por: Aggarwal, Shakti, et al.
Publicado: (2013)

Epithelial Sodium and Chloride Channels and Asthma
por: Wang, Wen, et al.
Publicado: (2015)

Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor
por: Stratiievska, Anastasiia, et al.
Publicado: (2018)

Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle
por: McCarron, John G., et al.
Publicado: (2009)

Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation
por: Yu, Guowu, et al.
Publicado: (2019)

Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced β-cell death
por: Wang, Xuan, et al.
Publicado: (2014)

Intracellular calcium changes induced by the endozepine triakontatetraneuropeptide in human polymorphonuclear leukocytes: role of protein kinase C and effect of calcium channel blockers
por: Marino, Franca, et al.
Publicado: (2004)

Berberine alleviates palmitic acid-induced podocyte apoptosis by reducing reactive oxygen species-mediated endoplasmic reticulum stress
por: Xiang, Xing-Yang, et al.
Publicado: (2021)

Systematic Review of Calcium Channels and Intracellular Calcium Signaling: Relevance to Pesticide Neurotoxicity
por: Costas-Ferreira, Carmen, et al.
Publicado: (2021)

Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response
por: Jeong, Jae Seok, et al.
Publicado: (2018)

The α(1D)-adrenergic receptor is expressed intracellularly and coupled to increases in intracellular calcium and reactive oxygen species in human aortic smooth muscle cells
por: García-Cazarín, Mary L, et al.
Publicado: (2008)

Evolutionarily conserved intracellular gate of voltage-dependent sodium channels
por: Oelstrom, Kevin, et al.
Publicado: (2014)

Phosphoinositide regulation of inward rectifier potassium (Kir) channels
por: Fürst, Oliver, et al.
Publicado: (2014)

Unmodified CdSe Quantum Dots Induce Elevation of Cytoplasmic Calcium Levels and Impairment of Functional Properties of Sodium Channels in Rat Primary Cultured Hippocampal Neurons
por: Tang, Mingliang, et al.
Publicado: (2008)

NaHS or Lovastatin Attenuates Cyclosporine A–Induced Hypertension in Rats by Inhibiting Epithelial Sodium Channels
por: Wang, Qiu-Shi, et al.
Publicado: (2021)

Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats
por: Yang, Xu, et al.
Publicado: (2020)

Early‐life atomic‐bomb irradiation accelerates immunological aging and elevates immune‐related intracellular reactive oxygen species
por: Hayashi, Tomonori, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3p3vekr82m808mkpgga36g1dsh