Cargando…

The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling

AIMS: Levo-tetrahydropalmatine (L-THP) is an active ingredient of Corydalis yanhusuo W. T. Wang, which has many bioactive properties. Herein, we investigated the protective effects of L-THP on concanavalin A- (ConA-) induced hepatitis in mice and explored its possible mechanisms of these effects. MA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Qiang, Liu, Tong, Li, Sainan, Feng, Jiao, Wu, Liwei, Wang, Wenwen, Chen, Kan, Xia, Yujing, Niu, Peiqin, Xu, Ling, Wang, Fan, Dai, Weiqi, Zhou, Yingqun, Guo, Chuanyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304924/ https://www.ncbi.nlm.nih.gov/pubmed/30622431 http://dx.doi.org/10.1155/2018/4032484

Ejemplares similares

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis
por: Li, Jingjing, et al.
Publicado: (2015)

Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis
por: Li, Jingjing, et al.
Publicado: (2016)

Levo-tetrahydropalmatine attenuates oxaliplatin-induced mechanical hyperalgesia in mice
por: Guo, Zhenggang, et al.
Publicado: (2014)

Preparation of the Levo-Tetrahydropalmatine Liposome Gel and Its Transdermal Study
por: Zhang, Guizhen, et al.
Publicado: (2023)

Levo-Tetrahydropalmatine Attenuates Bone Cancer Pain by Inhibiting Microglial Cells Activation
por: Zhang, Mao-yin, et al.
Publicado: (2015)

PPARγ/NF‐κB and TGF‐β1/Smad pathway are involved in the anti‐fibrotic effects of levo‐tetrahydropalmatine on liver fibrosis
por: Yu, Qiang, et al.
Publicado: (2021)

PM312. Combination of levo-tetrahydropalmatine and low dose naltrexone: a promising treatment for the prevention of cocaine relapse
por: Wang, Jia Bei, et al.
Publicado: (2016)

Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway
por: Liu, Tong, et al.
Publicado: (2016)

Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor
por: Kang, Dong-Wook, et al.
Publicado: (2016)

15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity
por: Chen, Kan, et al.
Publicado: (2014)

Erratum to “15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity”
por: Chen, Kan, et al.
Publicado: (2014)

AMPK-Mediated Metabolic Switching Is High Effective for Phytochemical Levo-Tetrahydropalmatine (l-THP) to Reduce Hepatocellular Carcinoma Tumor Growth
por: Yin, Xunzhe, et al.
Publicado: (2021)

Levo-tetrahydropalmatine attenuates mouse blood-brain barrier injury induced by focal cerebral ischemia and reperfusion: Involvement of Src kinase
por: Mao, Xiao-Wei, et al.
Publicado: (2015)

Levo-Tetrahydropalmatine Attenuates Progression of Abdominal Aortic Aneurysm in an Elastase Perfusion Rat Model via Suppression of Matrix Metalloproteinase and Monocyte Chemotactic Protein-1
por: Wang, Xin, et al.
Publicado: (2018)

Retracted: Levo-Tetrahydropalmatine Attenuates Progression of Abdominal Aortic Aneurysm in an Elastase Perfusion Rat Model via Suppression of Matrix Metalloproteinase and Monocyte Chemotactic Protein-1
por: Wang, Xin, et al.
Publicado: (2022)

Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury
por: Feng, Jiao, et al.
Publicado: (2018)

The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity
por: Xu, Shizan, et al.
Publicado: (2017)

Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice
por: Li, Jingjing, et al.
Publicado: (2017)

Ameliorated ConA-Induced Hepatitis in the Absence of PKC-theta
por: Fang, Xianfeng, et al.
Publicado: (2012)

Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway
por: Wu, Liwei, et al.
Publicado: (2017)

Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
por: Zheng, Wei, et al.
Publicado: (2016)

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways
por: Feng, Jiao, et al.
Publicado: (2018)

The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation
por: Wang, Wenwen, et al.
Publicado: (2018)

The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma
por: Li, Jingjing, et al.
Publicado: (2017)

Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death
por: Li, Sainan, et al.
Publicado: (2017)

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3
por: Li, Sainan, et al.
Publicado: (2016)

Splenectomy Promotes Macrophage Polarization in a Mouse Model of Concanavalin A- (ConA-) Induced Liver Fibrosis
por: Wang, Yongjuan, et al.
Publicado: (2019)

Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways
por: Deng, Jingfan, et al.
Publicado: (2018)

Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3
por: Xu, Ling, et al.
Publicado: (2016)

In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
por: Li, Sainan, et al.
Publicado: (2016)

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways
por: Wu, Liwei, et al.
Publicado: (2017)

N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway
por: Wang, Chengfen, et al.
Publicado: (2014)

l‐tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK‐TRAF6 interactions and inhibiting NF‐κB and MAPK pathways
por: Zhi, Xin, et al.
Publicado: (2019)

Sophocarpine Protects Mice from ConA-Induced Hepatitis via Inhibition of the IFN-Gamma/STAT1 Pathway
por: Sang, Xiu-Xiu, et al.
Publicado: (2017)

Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice
por: Li, Jingjing, et al.
Publicado: (2015)

Lepidium meyenii Walp Exhibits Anti-Inflammatory Activity against ConA-Induced Acute Hepatitis
por: Zheng, Wei, et al.
Publicado: (2018)

Selenium Promotes T-Cell Response to TCR-Stimulation and ConA, but Not PHA in Primary Porcine Splenocytes
por: Ren, Fei, et al.
Publicado: (2012)

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy
por: Li, Jingjing, et al.
Publicado: (2016)

ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships
por: Cavada, Benildo S., et al.
Publicado: (2018)

BRG1 Mediates Nephronectin Activation in Hepatocytes to Promote T Lymphocyte Infiltration in ConA-Induced Hepatitis
por: Hong, Wenxuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gjsfsfjhps8mitmvqsqr5er2ha