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Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development

The development of the fetal nervous system mirrors general fetal development, comprising a combination of genetic resources and effects of the intrauterine environment. Our aim was to assess the 2(nd) trimester amniotic fluid levels of brain-derived neurotrophic factor (BDNF) and to investigate its...

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Autores principales: Antonakopoulos, Nikolaos, Iliodromiti, Zoe, Mastorakos, George, Iavazzo, Christos, Valsamakis, Georgios, Salakos, Nikolaos, Papageorghiou, Aris, Margeli, Alexandra, Kalantaridou, Sophia, Creatsas, George, Deligeoroglou, Efthymios, Vrachnis, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304926/
https://www.ncbi.nlm.nih.gov/pubmed/30622436
http://dx.doi.org/10.1155/2018/8476217
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author Antonakopoulos, Nikolaos
Iliodromiti, Zoe
Mastorakos, George
Iavazzo, Christos
Valsamakis, Georgios
Salakos, Nikolaos
Papageorghiou, Aris
Margeli, Alexandra
Kalantaridou, Sophia
Creatsas, George
Deligeoroglou, Efthymios
Vrachnis, Nikolaos
author_facet Antonakopoulos, Nikolaos
Iliodromiti, Zoe
Mastorakos, George
Iavazzo, Christos
Valsamakis, Georgios
Salakos, Nikolaos
Papageorghiou, Aris
Margeli, Alexandra
Kalantaridou, Sophia
Creatsas, George
Deligeoroglou, Efthymios
Vrachnis, Nikolaos
author_sort Antonakopoulos, Nikolaos
collection PubMed
description The development of the fetal nervous system mirrors general fetal development, comprising a combination of genetic resources and effects of the intrauterine environment. Our aim was to assess the 2(nd) trimester amniotic fluid levels of brain-derived neurotrophic factor (BDNF) and to investigate its association with fetal growth. In accordance with our study design, samples of amniotic fluid were collected from women who had undergone amniocentesis early in the 2(nd) trimester. All pregnancies were followed up until delivery and fetal growth patterns and birth weights were recorded, following which pregnancies were divided into three groups based on fetal weight: (1) AGA (appropriate for gestational age), (2) SGA (small for gestational age), and (3) LGA (large for gestational age). We focused on these three groups representing a reflection of the intrauterine growth spectrum. Our results revealed the presence of notably higher BDNF levels in the amniotic fluid of impaired growth fetuses by comparison with those of normal growth. Both SGA and macrosomic fetuses are characterized by notably higher amniotic fluid levels of BDNF (mean values of 36,300 pg/ml and 35,700 pg/ml, respectively) compared to normal-growth fetuses (mean value of 32,700 pg/ml). Though apparently small, this difference is, nevertheless, statistically significant (p value < 0.05) in SGA fetuses in the extremes of the distribution, i.e., below the 3rd centile. In conclusion, there is clear evidence that severe impairment of fetal growth induces the increased production of fetal brain growth factor as an adaptive mechanism in reaction to a hostile intrauterine environment, thereby accelerating fetal brain development and maturation.
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spelling pubmed-63049262019-01-08 Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development Antonakopoulos, Nikolaos Iliodromiti, Zoe Mastorakos, George Iavazzo, Christos Valsamakis, Georgios Salakos, Nikolaos Papageorghiou, Aris Margeli, Alexandra Kalantaridou, Sophia Creatsas, George Deligeoroglou, Efthymios Vrachnis, Nikolaos Mediators Inflamm Research Article The development of the fetal nervous system mirrors general fetal development, comprising a combination of genetic resources and effects of the intrauterine environment. Our aim was to assess the 2(nd) trimester amniotic fluid levels of brain-derived neurotrophic factor (BDNF) and to investigate its association with fetal growth. In accordance with our study design, samples of amniotic fluid were collected from women who had undergone amniocentesis early in the 2(nd) trimester. All pregnancies were followed up until delivery and fetal growth patterns and birth weights were recorded, following which pregnancies were divided into three groups based on fetal weight: (1) AGA (appropriate for gestational age), (2) SGA (small for gestational age), and (3) LGA (large for gestational age). We focused on these three groups representing a reflection of the intrauterine growth spectrum. Our results revealed the presence of notably higher BDNF levels in the amniotic fluid of impaired growth fetuses by comparison with those of normal growth. Both SGA and macrosomic fetuses are characterized by notably higher amniotic fluid levels of BDNF (mean values of 36,300 pg/ml and 35,700 pg/ml, respectively) compared to normal-growth fetuses (mean value of 32,700 pg/ml). Though apparently small, this difference is, nevertheless, statistically significant (p value < 0.05) in SGA fetuses in the extremes of the distribution, i.e., below the 3rd centile. In conclusion, there is clear evidence that severe impairment of fetal growth induces the increased production of fetal brain growth factor as an adaptive mechanism in reaction to a hostile intrauterine environment, thereby accelerating fetal brain development and maturation. Hindawi 2018-12-05 /pmc/articles/PMC6304926/ /pubmed/30622436 http://dx.doi.org/10.1155/2018/8476217 Text en Copyright © 2018 Nikolaos Antonakopoulos et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Antonakopoulos, Nikolaos
Iliodromiti, Zoe
Mastorakos, George
Iavazzo, Christos
Valsamakis, Georgios
Salakos, Nikolaos
Papageorghiou, Aris
Margeli, Alexandra
Kalantaridou, Sophia
Creatsas, George
Deligeoroglou, Efthymios
Vrachnis, Nikolaos
Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development
title Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development
title_full Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development
title_fullStr Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development
title_full_unstemmed Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development
title_short Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2(nd) Trimester Amniotic Fluid and Fetal Development
title_sort association between brain-derived neurotrophic factor (bdnf) levels in 2(nd) trimester amniotic fluid and fetal development
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304926/
https://www.ncbi.nlm.nih.gov/pubmed/30622436
http://dx.doi.org/10.1155/2018/8476217
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