Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model

BACKGROUND: Debio 1143, a potent orally available SMAC mimetic, targets inhibitors of apoptosis proteins (IAPs) members and is currently in clinical trials. In this study, nuclear imaging evaluated the effects of Debio 1143 on tumor cell death and metabolism in a triple-negative breast cancer (TNBC)...

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Detalles Bibliográficos
Autores principales: Bellaye, Pierre-Simon, Oudot, Alexandra, Vrigneaud, Jean-Marc, Raguin, Olivier, Bichat, Francis, Vaslin, Anne, Maby-El Hajjami, Hélène, Zanna, Claudio, Vuagniaux, Grégoire, Fumoleau, Pierre, Denat, Franck, Brunotte, François, Collin, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305031/
https://www.ncbi.nlm.nih.gov/pubmed/30627061
http://dx.doi.org/10.1155/2018/8494031

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