An Improved Receptor-Based Pharmacophore Generation Algorithm Guided by Atomic Chemical Characteristics and Hybridization Types

Pharmacophore-based virtual screening is an important and leading compound discovery method. However, current pharmacophore generation algorithms suffer from difficulties, such as ligand-dependent computation and massive extractive chemical features. On the basis of the features extracted by the fiv...

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Detalles Bibliográficos
Autores principales: He, Gaoqi, Gong, Bojie, Li, Jianqiang, Song, Yiping, Li, Shiliang, Lu, Xingjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305075/
https://www.ncbi.nlm.nih.gov/pubmed/30618755
http://dx.doi.org/10.3389/fphar.2018.01463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305075/
https://www.ncbi.nlm.nih.gov/pubmed/30618755
http://dx.doi.org/10.3389/fphar.2018.01463

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