Cargando…

Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis

Angiotensin-converting enzyme (ACE) gene is indispensable for endothelial control and vascular tone regulatory systems, usually affected in Systemic Lupus Erythematosus (SLE). ACE insertion/deletion (I/D) polymorphism may influence the progress of SLE. Earlier studies have investigated this associat...

Descripción completa

Detalles Bibliográficos
Autores principales: Khan, Saif, Dar, Sajad A., Mandal, Raju K., Jawed, Arshad, Wahid, Mohd, Panda, Aditya K., Lohani, Mohtashim, Mishra, B. N., Akhter, Naseem, Haque, Shafiul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305102/
https://www.ncbi.nlm.nih.gov/pubmed/30618805
http://dx.doi.org/10.3389/fphys.2018.01793
_version_ 1783382489366003712
author Khan, Saif
Dar, Sajad A.
Mandal, Raju K.
Jawed, Arshad
Wahid, Mohd
Panda, Aditya K.
Lohani, Mohtashim
Mishra, B. N.
Akhter, Naseem
Haque, Shafiul
author_facet Khan, Saif
Dar, Sajad A.
Mandal, Raju K.
Jawed, Arshad
Wahid, Mohd
Panda, Aditya K.
Lohani, Mohtashim
Mishra, B. N.
Akhter, Naseem
Haque, Shafiul
author_sort Khan, Saif
collection PubMed
description Angiotensin-converting enzyme (ACE) gene is indispensable for endothelial control and vascular tone regulatory systems, usually affected in Systemic Lupus Erythematosus (SLE). ACE insertion/deletion (I/D) polymorphism may influence the progress of SLE. Earlier studies have investigated this association without any consistency in results. We performed this meta-analysis to evaluate the precise association between ACE I/D polymorphism and SLE susceptibility. The relevant studies were searched until December, 2017 using Medline (PubMed), Google-Scholar and EMBASE search engines. Twenty-five published studies involving 3,308 cases and 4,235 controls were included in this meta-analysis. Statistically significant increased risk was found for allelic (D vs. I: p = 0.007; OR = 1.202, 95% CI = 1.052–1.374), homozygous (DD vs. II: p = 0.025; OR = 1.347, 95% CI = 1.038–1.748), dominant (DD+ID vs. II: p = 0.002; OR = 1.195, 95% CI = 1.070–1.334), and recessive (DD vs. ID+II: p = 0.023; OR = 1.338, 95% CI = 1.042–1.718) genetic models. Subgroup analysis stratified by Asian ethnicity revealed significant risk of SLE in allelic (D vs. I: p = 0.045; OR = 1.238, 95% CI = 1.005–1.525) and marginal risk in dominant (DD+ID vs. II: p = 0.056; OR = 1.192, 95% CI = 0.995–1.428) models; whereas, no association was observed for Caucasian and African population. Publication bias was absent. In conclusion, ACE I/D polymorphism has significant role in overall SLE risk and it can be exploited as a prognostic marker for early SLE predisposition.
format Online
Article
Text
id pubmed-6305102
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-63051022019-01-07 Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis Khan, Saif Dar, Sajad A. Mandal, Raju K. Jawed, Arshad Wahid, Mohd Panda, Aditya K. Lohani, Mohtashim Mishra, B. N. Akhter, Naseem Haque, Shafiul Front Physiol Physiology Angiotensin-converting enzyme (ACE) gene is indispensable for endothelial control and vascular tone regulatory systems, usually affected in Systemic Lupus Erythematosus (SLE). ACE insertion/deletion (I/D) polymorphism may influence the progress of SLE. Earlier studies have investigated this association without any consistency in results. We performed this meta-analysis to evaluate the precise association between ACE I/D polymorphism and SLE susceptibility. The relevant studies were searched until December, 2017 using Medline (PubMed), Google-Scholar and EMBASE search engines. Twenty-five published studies involving 3,308 cases and 4,235 controls were included in this meta-analysis. Statistically significant increased risk was found for allelic (D vs. I: p = 0.007; OR = 1.202, 95% CI = 1.052–1.374), homozygous (DD vs. II: p = 0.025; OR = 1.347, 95% CI = 1.038–1.748), dominant (DD+ID vs. II: p = 0.002; OR = 1.195, 95% CI = 1.070–1.334), and recessive (DD vs. ID+II: p = 0.023; OR = 1.338, 95% CI = 1.042–1.718) genetic models. Subgroup analysis stratified by Asian ethnicity revealed significant risk of SLE in allelic (D vs. I: p = 0.045; OR = 1.238, 95% CI = 1.005–1.525) and marginal risk in dominant (DD+ID vs. II: p = 0.056; OR = 1.192, 95% CI = 0.995–1.428) models; whereas, no association was observed for Caucasian and African population. Publication bias was absent. In conclusion, ACE I/D polymorphism has significant role in overall SLE risk and it can be exploited as a prognostic marker for early SLE predisposition. Frontiers Media S.A. 2018-12-17 /pmc/articles/PMC6305102/ /pubmed/30618805 http://dx.doi.org/10.3389/fphys.2018.01793 Text en Copyright © 2018 Khan, Dar, Mandal, Jawed, Wahid, Panda, Lohani, Mishra, Akhter and Haque. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Khan, Saif
Dar, Sajad A.
Mandal, Raju K.
Jawed, Arshad
Wahid, Mohd
Panda, Aditya K.
Lohani, Mohtashim
Mishra, B. N.
Akhter, Naseem
Haque, Shafiul
Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis
title Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis
title_full Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis
title_fullStr Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis
title_full_unstemmed Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis
title_short Angiotensin-Converting Enzyme Gene I/D Polymorphism Is Associated With Systemic Lupus Erythematosus Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis
title_sort angiotensin-converting enzyme gene i/d polymorphism is associated with systemic lupus erythematosus susceptibility: an updated meta-analysis and trial sequential analysis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305102/
https://www.ncbi.nlm.nih.gov/pubmed/30618805
http://dx.doi.org/10.3389/fphys.2018.01793
work_keys_str_mv AT khansaif angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT darsajada angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT mandalrajuk angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT jawedarshad angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT wahidmohd angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT pandaadityak angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT lohanimohtashim angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT mishrabn angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT akhternaseem angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis
AT haqueshafiul angiotensinconvertingenzymegeneidpolymorphismisassociatedwithsystemiclupuserythematosussusceptibilityanupdatedmetaanalysisandtrialsequentialanalysis