Neoadjuvant administration of hydroxychloroquine in a phase 1 clinical trial induced plasma Par-4 levels and apoptosis in diverse tumors

Chloroquine and hydroxychloroquine (HCQ) are robust inducers of the tumor suppressor Par-4 secretion from normal cells. Secreted Par-4 causes paracrine apoptosis of tumor cells and inhibits metastasis in mice. We report the clinical results with pharmacodynamic analyses of our Phase I trial using ne...

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Detalles Bibliográficos
Autores principales: Wang, Peng, Burikhanov, Ravshan, Jayswal, Rani, Weiss, Heidi L., Arnold, Susanne M., Villano, John L., Rangnekar, Vivek M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305107/
https://www.ncbi.nlm.nih.gov/pubmed/30603055
http://dx.doi.org/10.18632/genesandcancer.181

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