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Primary Vaginal Chloroma: A Rare Case Report

Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. Here we are presenting a rare case of chloroma in a female patien...

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Autores principales: Madabhavi, Irappa, Patel, Apurva, Modi, Mitul, Revannasiddaiah, Swaroop, Chavan, Chidanand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305264/
https://www.ncbi.nlm.nih.gov/pubmed/30595816
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author Madabhavi, Irappa
Patel, Apurva
Modi, Mitul
Revannasiddaiah, Swaroop
Chavan, Chidanand
author_facet Madabhavi, Irappa
Patel, Apurva
Modi, Mitul
Revannasiddaiah, Swaroop
Chavan, Chidanand
author_sort Madabhavi, Irappa
collection PubMed
description Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. Here we are presenting a rare case of chloroma in a female patient without initial presentation of AML. 38 year old female patient, with performance score-1 had complaining of per vaginal bleeding for 1-2 days. Patient consulted gynaecologist and underwent biopsy from anterior fornix of vagina. Biopsy material was positive for LCA (leukocyte common antigen), MPO (myeloperoxidase), c-kit positive on IHC (immunohistocytochemistry) while negative for cytokeratin, synaptophysin, chromogranin, CD20 (cluster of differentiation. Whole body CT scan was non informative except mass lesion at vagina. Patient was given 3+7 induction chemotherapy which was tolerated well followed by high dose cytarabine as consolidation therapy.
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spelling pubmed-63052642018-12-28 Primary Vaginal Chloroma: A Rare Case Report Madabhavi, Irappa Patel, Apurva Modi, Mitul Revannasiddaiah, Swaroop Chavan, Chidanand Int J Hematol Oncol Stem Cell Res Case Report Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. Here we are presenting a rare case of chloroma in a female patient without initial presentation of AML. 38 year old female patient, with performance score-1 had complaining of per vaginal bleeding for 1-2 days. Patient consulted gynaecologist and underwent biopsy from anterior fornix of vagina. Biopsy material was positive for LCA (leukocyte common antigen), MPO (myeloperoxidase), c-kit positive on IHC (immunohistocytochemistry) while negative for cytokeratin, synaptophysin, chromogranin, CD20 (cluster of differentiation. Whole body CT scan was non informative except mass lesion at vagina. Patient was given 3+7 induction chemotherapy which was tolerated well followed by high dose cytarabine as consolidation therapy. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2018-07-01 /pmc/articles/PMC6305264/ /pubmed/30595816 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Madabhavi, Irappa
Patel, Apurva
Modi, Mitul
Revannasiddaiah, Swaroop
Chavan, Chidanand
Primary Vaginal Chloroma: A Rare Case Report
title Primary Vaginal Chloroma: A Rare Case Report
title_full Primary Vaginal Chloroma: A Rare Case Report
title_fullStr Primary Vaginal Chloroma: A Rare Case Report
title_full_unstemmed Primary Vaginal Chloroma: A Rare Case Report
title_short Primary Vaginal Chloroma: A Rare Case Report
title_sort primary vaginal chloroma: a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305264/
https://www.ncbi.nlm.nih.gov/pubmed/30595816
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AT chavanchidanand primaryvaginalchloromaararecasereport